Evaluation of Inactivated Vaccine-Induced Protection against Grouper Iridovirus

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Project title

Code/計畫編號

92農科-4.2.3-漁-F1(13)

Translated Name/計畫中文名

石斑虹彩病毒不活化疫苗保護作用之評估

Project Coordinator/計畫主持人

Hsin-Yiu Chou

Funding Organization/主管機關

Council of Agriculture,Executive Yuan

Department/Unit

Department of Aquaculture

Website

https://www.grb.gov.tw/search/planDetail?id=960843

Year

2003

Start date/計畫起

01-01-2003

Expected Completion/計畫迄

31-12-2003

Bugetid/研究經費

600千元

ResearchField/研究領域

漁業

"本研究室針對台灣石斑虹彩病毒(grouper iridovirus of Taiwan,簡稱TGIV)發展出具100%保護效果之不活化疫苗,本年度希望進一步評估此疫苗的穩定性和安全性,以確認實際應用之可行性.疫苗雖是解決魚類病毒性疾病的重要防治對策之一,但如成本偏高、施用方式的選擇、以及緊迫與有效性等問題仍待解決,因此目前只有極少數的疫苗成為商品化.本計畫擬建立石斑魚特異性和非特異性免疫參數,作為評估石斑魚免疫反應之工具;同時由免疫後魚苗的活存率和魚體內病毒殘留分析的結果,確認所開發出之石斑虹彩病毒不活化疫苗的安全性和穩定性,若能進一步實際應用石斑魚的繁養殖場,將有助於虹彩病毒感染症防治工作的施行." "Vaccine development is one of the major approaches of controlling viral diseases in aquaculture. Unfortunately, in consideration of detailed items of vaccination, such as cost, stress and efficacy, there are only a few of commercially available vaccines for fish viral pathogens to date. In our previous studies, vaccines based on inactivated treatment of TGIV have been demonstrated to be very efficient in increasing survival rate under TGIV challenge tests. To aim at field tests and practical uses of the TGIV vaccine, stability and safety claim attention in this project. Therefore, for better understand of immune responses occur in grouper after vaccination, specific and nonspecific immune parameters will be established in first. Moreover, for practicability concerns, recurrence and residual infectivity of the developed vaccine are estimated as well. Finally, the results of this study will help to establish information for practicable use of TGIV vaccine and control of the disease."

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Evaluation of Inactivated Vaccine-Induced Protection against Grouper Iridovirus

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