http://scholars.ntou.edu.tw/handle/123456789/189 2026-04-25T05:55:28Z 2026-04-25T05:55:28Z Wu, Jim-Wei Hsu, Ting-Kuei Li, Jia-Cheng Lin, Yu-Han Chen, Sung-Hua http://scholars.ntou.edu.tw/handle/123456789/26468 2026-03-12T03:36:49Z 2025-01-01T00:00:00Z

標題: Globally smooth lemniscate trajectory with adaptive integral terminal sliding mode control and inversion-based hysteresis compensation for pi ezoelectric stage precise tracking 作者: Wu, Jim-Wei; Hsu, Ting-Kuei; Li, Jia-Cheng; Lin, Yu-Han; Chen, Sung-Hua 摘要: High-precision measurement systems use an xy-axis piezoelectric scanner following a pre-determined trajectory to achieve three-dimensional scanning at micro/nano-scales. Most systems employ a raster scanning trajectory due to ease of implementation; however, raster scanning generates infinite odd harmonics, which can induce mechanical resonance leading to image distortion. Moreover, the nonlinear response characteristics of piezoelectric materials frequently result in unexpected displacements. This paper presents a novel sequential scanning trajectory that eliminates the need for a step function and minimizes the risk of mapping errors. An advanced controller combining an inverse hysteresis model with adaptive integral terminal sliding mode control (AITSMC) was developed and first applied in the piezoelectric scanner through theoretical derivation and stability analysis to prove its feasibility. In simulations and experiments, the proposed controller significantly mitigated the effects of hysteresis during trajectory tracking and achieved superior tracking accuracy and lower RMSE compared to existing sliding mode controllers.

2025-01-01T00:00:00Z Wu, Chun-, I Tseng, Wei-Lun Wang, Bo-Xiang http://scholars.ntou.edu.tw/handle/123456789/26453 2026-03-12T03:36:45Z 2025-01-01T00:00:00Z

標題: Numerical analysis of flow configuration and channel design for thermoelectric OTEC systems 作者: Wu, Chun-, I; Tseng, Wei-Lun; Wang, Bo-Xiang 摘要: This research examines the optimized integration of Bi2Te3-based thermoelectric generators (TEGs) in Ocean Thermal Energy Conversion (OTEC) systems, evaluating their performance via detailed numerical analysis. We conducted finite element simulations using COMSOL Multiphysics to analyze thermoelectric generators (TEGs) placed between a warm surface and cold deep seawater channels under different operational conditions. The research examined parallel and counter flow configurations at Reynolds numbers between 3987 and 73,800, with channel heights varying from 0.002 to 0.072 m. Results indicate that Reynolds numbers above 12,000 ensure stable heat supply to TEGs, resulting in a consistent output power of 3.01 W. The optimal net power of 1.45 W was attained at a channel height of 0.002 m, attributed to reduced pump power consumption. A comparative analysis of Bi2Te3-based material combinations demonstrated that improved electrical and decreased thermal conductivity notably enhanced system performance. This study offers essential insights for improving the design and implementation of TEG-OTEC systems, especially in offshore contexts where operational efficiency and system durability are critical, thereby contributing to the advancement of sustainable ocean energy technologies.

2025-01-01T00:00:00Z Lin, Yu-Chih Lin, Sih-You Kao, Shih-Yu http://scholars.ntou.edu.tw/handle/123456789/26389 2026-03-12T03:36:26Z 2025-01-01T00:00:00Z

標題: Investigations on the Effects of a Passive Standing-from-Squatting and Gait Assistive Exoskeleton on Human Motion 作者: Lin, Yu-Chih; Lin, Sih-You; Kao, Shih-Yu 摘要: The aim of this study is to examine the biomechanical interaction between an assistive wearable exoskeleton and the human body. For this purpose, a passive exoskeleton is designed to provide support during the transition from a squatting position to standing, while also enabling the resilient components to become active during the initial and mid-swing phases of level walking. The active period can be adjusted by a slot, which triggers the activation of the resilient components when the exoskeleton's flexion angle exceeds a critical value. This study also compares the effect of using different passive powered components in the exoskeleton. Electromyography (EMG) signals and angular velocity during human motion are collected and analyzed. Experimental results indicate that the designed assistive exoskeleton effectively reduces muscle effort during squatting/standing motion, as intended. The exoskeleton reduces the flexion/extension (x-axis) angular velocity during both squatting/standing and the swing phase of gait. The oscillation of the angular velocity curve about the y-axis during gait is larger without the exoskeleton, suggesting that the exoskeleton may introduce interference but also a stabilizing effect in certain dimensions during gait. This study provides a stronger foundation for advancing the design of both passive and active powered exoskeletons.

2025-01-01T00:00:00Z Lin, Chi Chao, Hsin-Yi Cheng, Tsai-Mu Shih, Chun-Ming Wu, Alexander T. H. Cheng, Chia-Hsiung Hsiao, Chen Yuan Lu, Hsin-Ying Shih, Chun-Che Mi, Fwu-Long http://scholars.ntou.edu.tw/handle/123456789/26263 2026-03-12T03:20:44Z 2026-01-01T00:00:00Z

標題: Pathology-tailored nanotherapy via Galectin-3-targeted and triple-responsive nanoparticles enables multimodal therapy against aortic dissection 作者: Lin, Chi; Chao, Hsin-Yi; Cheng, Tsai-Mu; Shih, Chun-Ming; Wu, Alexander T. H.; Cheng, Chia-Hsiung; Hsiao, Chen Yuan; Lu, Hsin-Ying; Shih, Chun-Che; Mi, Fwu-Long 摘要: Aortic dissection (AD) is a life-threatening vascular disorder with high mortality and no effective pharmacological treatment. Addressing its multicellular and dynamic pathology requires strategies that precisely modulate inflammatory and degenerative processes, yet existing targeted delivery approaches lack the spatiotemporal and cellular precision required. Here, we establish Galectin-3 (Gal-3) as a therapeutic delivery target for cardiovascular nanomedicine and introduce a modular, pathology-tailored nanoplatform synergizing nitric oxide (NO) therapy with multi-pathway intervention. Gal-3 is persistently expressed on inflamed endothelial cells, macrophages, and smooth muscle cells during AD progression, providing a tractable target for lesion-specific engagement. The nanoparticles, created from a previously unexplored integration of a Gal-3-binding polysaccharide, a nitric oxide-generating peptide, and a hydrophobic drug carrier, uniquely combine triple responsiveness to pH, protease, and oxidative stress with on-demand NO release and controlled resveratrol co-delivery. In vitro, they enhanced uptake across pathological cell types and attenuated inflammatory and degenerative phenotypes. In vivo, they achieved early lesion targeting, > 20-fold aortic accumulation, and marked reductions in AD incidence, vascular degeneration, and mortality. This work establishes Gal-3-targeted nanotherapy as a broadly applicable paradigm for pathology-adaptive intervention in AD and one that may be adapted for broader cardiovascular applications.

2026-01-01T00:00:00Z