http://scholars.ntou.edu.tw/handle/123456789/188 2026-04-08T12:05:48Z http://scholars.ntou.edu.tw/handle/123456789/26455 標題: Electrically-Driven 2D Semiconductor Microcavity Laser 作者: Chen, Zheng-Zhe; Lin, Hsiang-Ting; Chang, Chiao-Yun; Adil, Muhammad; Tsai, Po-Cheng; Kao, Tsung Sheng; Chen, Chi; Lin, Shih-Yen; Shih, Min-Hsiung 摘要: 2D monolayered transition-metal dichalcogenides (TMDCs) are promising materials for realizing ultracompact, low-threshold semiconductor lasers. And the development of the electrical-driven TMDC devices is crucial for enhancing the integration potential of practical optoelectronic systems. However, at the current stage, the electrically-driven 2-D TMDC laser has never been realized. Herein, the first electrically-driven 2-D TMDC microcavity laser have been developed. In this device, an alternating current (AC) generates electroluminescence lasing in suspended monolayered WSe2 integrated on a microdisk cavity. The input-output curve, bandwidth narrowing, and second-order coherence is analyzed to confirm the lasing characteristics at room temperature. The realization of the room-temperature AC-driven 2-D TMDC laser establishes a new area of research on electrically pumped compact lasers and is likely to assist with the implementation of diverse TMDC-based practical photonic devices in the future. 2025-01-01T00:00:00Z http://scholars.ntou.edu.tw/handle/123456789/26366 標題: Risk-based integrated framework for evaluating effects of microplastics to aquatic ecosystems and human health 作者: Shiu, Ruei-Feng; Chen, Tzu-Jung; Nan, Fan-Hua; Tsao, Hsiao-Chang; Ling, Min-Pei 摘要: The widespread presence of microplastics (MPs) in environments and the food web is a serious concern for both aquatic ecosystems and human health. Most studies have used single tool to assess risks primarily to organisms and humans, leaving gaps in comprehensive risk assessments. This study conducted an investigation of MP abundances in surface water and wild oysters from natural estuaries of major rivers in Taiwan. Additionally, the data also used to develop an integrated risk-based framework for evaluating potential risks from organisms to human MP exposure to seafood consumption. We assessed aquatic ecological risk quotients (RQ), oyster mortality exceedance risk (ER), human MP intake exposure, and human liver damage ER. Our data showed that MP abundances ranged from 0.025 to 4.701 items/m3 and 0.015-2.374 items/g (wet weight) in water and oysters, respectively. Although RQ values indicate negligible risk for aquatic ecosystems, but oyster mortality ER results from oysters exposed to MPs showed a 6 % increase in mortality (10 % risk). The probabilistic representation of risk curves of MPs for alanine aminotransferase (ALT) levels in human serum was found to be low, indicating minimal health risk to humans. Overall, our data suggest that relying on a single risk indicator may underestimate potential risks, multi-faceted tools are recommended for assessing organism and human health. 2025-01-01T00:00:00Z http://scholars.ntou.edu.tw/handle/123456789/26263 標題: Pathology-tailored nanotherapy via Galectin-3-targeted and triple-responsive nanoparticles enables multimodal therapy against aortic dissection 作者: Lin, Chi; Chao, Hsin-Yi; Cheng, Tsai-Mu; Shih, Chun-Ming; Wu, Alexander T. H.; Cheng, Chia-Hsiung; Hsiao, Chen Yuan; Lu, Hsin-Ying; Shih, Chun-Che; Mi, Fwu-Long 摘要: Aortic dissection (AD) is a life-threatening vascular disorder with high mortality and no effective pharmacological treatment. Addressing its multicellular and dynamic pathology requires strategies that precisely modulate inflammatory and degenerative processes, yet existing targeted delivery approaches lack the spatiotemporal and cellular precision required. Here, we establish Galectin-3 (Gal-3) as a therapeutic delivery target for cardiovascular nanomedicine and introduce a modular, pathology-tailored nanoplatform synergizing nitric oxide (NO) therapy with multi-pathway intervention. Gal-3 is persistently expressed on inflamed endothelial cells, macrophages, and smooth muscle cells during AD progression, providing a tractable target for lesion-specific engagement. The nanoparticles, created from a previously unexplored integration of a Gal-3-binding polysaccharide, a nitric oxide-generating peptide, and a hydrophobic drug carrier, uniquely combine triple responsiveness to pH, protease, and oxidative stress with on-demand NO release and controlled resveratrol co-delivery. In vitro, they enhanced uptake across pathological cell types and attenuated inflammatory and degenerative phenotypes. In vivo, they achieved early lesion targeting, > 20-fold aortic accumulation, and marked reductions in AD incidence, vascular degeneration, and mortality. This work establishes Gal-3-targeted nanotherapy as a broadly applicable paradigm for pathology-adaptive intervention in AD and one that may be adapted for broader cardiovascular applications. 2026-01-01T00:00:00Z http://scholars.ntou.edu.tw/handle/123456789/26238 標題: Evolutionary adaptation of anaerobic and aerobic metabolism to high sulfide and hypoxic hydrothermal vent crab, Xenograpsus testudinatus 作者: Chen, Chi; Wu, Guan-Chung; Tseng, Yung-Che; Dufour, Sylvie; Chang, Ching-Fong 摘要: The vent crab, Xenograpsus testudinatus (xtcrab), is adapted to inhabit shallow-water, high sulfide and hypoxic hydrothermal vent. Our previous study revealed sulfide tolerance of vent xtcrabs which sulfide: quinone oxidoreductase (xtSQR) paralogs aid in sulfide detoxification. However, the mechanisms of how xtcrab adapts to high sulfide-hypoxic conditions in the vent area remain to be explored. In the present study, we tested the tolerance of xtcrab to sulfide-induced hypoxia, and investigated their aerobic and anaerobic responses in situ and in the laboratory. Comparisons were made to a non-vent, intertidal species, Thranita danae (tdcrab). We analyzed the several factors related to aerobic metabolism (SQR, cytochrome c [CYTC], complex IV [COXIV]), the product of anaerobic metabolism (hemolymph lactate levels) and glucose levels. Our results showed a higher survival tolerance to hypoxia of xtcrabs than tdcrabs. Hemolymph lactate levels increased more rapidly in xtcrabs than tdcrabs exposed to experimental hypoxia, revealing a rapid induction of anaerobic metabolism in hypoxic xtcrabs. Lactate measurement in xtcrabs returned from aquaria to original capture sites (vent habitats), further assessed the remarkable ability of xtcrabs to rapidly switch on and off their anaerobic metabolism. To assess aerobic metabolism, long-term exposure of xtcrabs to hydrothermal vent habitat increased gill xtCYTC transcripts and protein levels together with steadily enzymatic activity of COXIV. This revealed ability of xtcrabs to maintain functional capacity of aerobic respiration in hypoxia. Phylogenetic analysis showed that xtSQR paralogs in xtcrabs were more distant compared to tdSQR paralogs in tdcrabs. The increase of transcripts and enzymatic activity of gill xtSQR, and co-localization of xtSQR and xtCYTC also contribute to maintain aerobic metabolism by preventing sulfide toxicity on mitochondrial respiratory function. Overall, our study suggests that multiple strategies including detoxification of sulfide by gill xtSQR, and a quick/dynamic switch between aerobic and anaerobic metabolisms may play important roles in the metabolic adaptations of xtcrabs to extreme hydrothermal vent environment. 2025-01-01T00:00:00Z