http://scholars.ntou.edu.tw/handle/123456789/17180
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Nain, Amit | en_US |
dc.contributor.author | Wei, Shih-Chun | en_US |
dc.contributor.author | Lin, Yu-Feng | en_US |
dc.contributor.author | Tseng, Yu-Ting | en_US |
dc.contributor.author | Mandal, Ranju Prasad | en_US |
dc.contributor.author | Huang, Yu-Fen | en_US |
dc.contributor.author | Huang, Chih-Ching | en_US |
dc.contributor.author | Tseng, Fan-Gang | en_US |
dc.contributor.author | Chang, Huan-Tsung | en_US |
dc.date.accessioned | 2021-06-10T01:07:35Z | - |
dc.date.available | 2021-06-10T01:07:35Z | - |
dc.date.issued | 2021-02-24 | - |
dc.identifier.issn | 1944-8244 | - |
dc.identifier.uri | http://scholars.ntou.edu.tw/handle/123456789/17180 | - |
dc.description.abstract | Bovine serum albumin (BSA)-encapsulated copper sulfide nanocrystals (CuS NCs) were prepared by heating an alkaline solution containing copper ions and BSA without an additional sulfur source. At a high BSA concentration (0.8 mM), nanoassembly of the as-formed CuS NCs occurs to form BSA-CuS NCs as a result of the formation of BSA gel-like structures. In addition to their intrinsic photothermal properties, the BSA-CuS NCs possess rich surface vacancies and thus exhibit enzyme-like and photodynamic activities. Spontaneous generation of hydrogen peroxide (H2O2) led to the in situ formation of copper peroxide (CPO) nanodots on the BSA-CuS NCs to catalyze singlet oxygen radical generation. The antimicrobial response was enhanced by >60-fold upon NIR laser irradiation, which was ascribed to the combined effect of the photodynamic and photothermal inactivation of bacteria. Furthermore, BSA-CuS NCs were transdermally administered onto a methicillin-resistant Staphylococcus aureus-infected wound and eradicated >99% of bacteria in just 1 min under NIR illumination due to the additional peroxidase-like activity of BSA-CuS NCs, transforming H2O2 at the infection site into hydroxyl radicals and thus increasing the synergistic effect from photodynamic and photothermal treatment. The BSA-CuS NCs exhibited insignificant in vitro cytotoxicity and hemolysis and thus can serve as highly biocompatible bactericides in preclinical applications to effectively eradicate bacteria. | en_US |
dc.language.iso | English | en_US |
dc.publisher | AMER CHEMICAL SOC | en_US |
dc.relation.ispartof | ACS APPLIED MATERIALS & INTERFACES | en_US |
dc.subject | proteins | en_US |
dc.subject | copper sulfide nanoassemblies | en_US |
dc.subject | copper peroxide nanodots | en_US |
dc.subject | reactive oxygen species | en_US |
dc.subject | photoresponsive agents | en_US |
dc.subject | wound infection | en_US |
dc.title | Copper Sulfide Nanoassemblies for Catalytic and Photoresponsive Eradication of Bacteria from Infected Wounds | en_US |
dc.type | journal article | en_US |
dc.identifier.doi | 10.1021/acsami.0c18999 | - |
dc.identifier.isi | WOS:000623228500004 | - |
dc.relation.journalvolume | 13 | en_US |
dc.relation.journalissue | 7 | en_US |
dc.relation.pages | 7865-7878 | en_US |
item.cerifentitytype | Publications | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.fulltext | no fulltext | - |
item.grantfulltext | none | - |
item.languageiso639-1 | English | - |
crisitem.author.dept | College of Life Sciences | - |
crisitem.author.dept | Department of Bioscience and Biotechnology | - |
crisitem.author.dept | National Taiwan Ocean University,NTOU | - |
crisitem.author.dept | Center of Excellence for the Oceans | - |
crisitem.author.orcid | 0000-0002-0363-1129 | - |
crisitem.author.parentorg | National Taiwan Ocean University,NTOU | - |
crisitem.author.parentorg | College of Life Sciences | - |
crisitem.author.parentorg | National Taiwan Ocean University,NTOU | - |
Appears in Collections: | 生命科學暨生物科技學系 |
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