http://scholars.ntou.edu.tw/handle/123456789/17395
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chou, Ding-Li | en_US |
dc.contributor.author | Mao, Ju-Yi | en_US |
dc.contributor.author | Anand, Anisha | en_US |
dc.contributor.author | Lin, Han-Jia | en_US |
dc.contributor.author | Lin, John Han-You | en_US |
dc.contributor.author | Tseng, Ching-Ping | en_US |
dc.contributor.author | Huang, Chih-Ching | en_US |
dc.contributor.author | Wang, Hsian-Yu | en_US |
dc.date.accessioned | 2021-07-06T04:58:25Z | - |
dc.date.available | 2021-07-06T04:58:25Z | - |
dc.date.issued | 2021-06-01 | - |
dc.identifier.uri | http://scholars.ntou.edu.tw/handle/123456789/17395 | - |
dc.description.abstract | In this study, we demonstrate the synthesis of carbonized nanogels (CNGs) from an amino acid (lysine hydrochloride) using a simple pyrolysis method, resulting in effective viral inhibition properties against infectious bronchitis virus (IBV). The viral inhibition of CNGs was studied using both in vitro (bovine ephemeral fever virus (BEFV) and pseudorabies virus (PRV)) and in ovo (IBV) models, which indicated that the CNGs were able to prevent virus attachment on the cell membrane and penetration into the cell. A very low concentration of 30 mu g mL(-1) was found to be effective (>98% inhibition) in IBV-infected chicken embryos. The hatching rate and pathology of IBV-infected chicken embryos were greatly improved in the presence of CNGs. CNGs with distinctive virus-neutralizing activities show great potential as a virostatic agent to prevent the spread of avian viruses and to alleviate the pathology of infected avian species. | en_US |
dc.language.iso | English | en_US |
dc.publisher | MDPI | en_US |
dc.relation.ispartof | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | en_US |
dc.subject | lysine | en_US |
dc.subject | carbonization | en_US |
dc.subject | nanogels | en_US |
dc.subject | infectious bronchitis virus | en_US |
dc.subject | antiviral agents | en_US |
dc.title | Carbonized Lysine-Nanogels Protect against Infectious Bronchitis Virus | en_US |
dc.type | journal article | en_US |
dc.identifier.doi | 10.3390/ijms22115415 | - |
dc.identifier.isi | WOS:000660173100001 | - |
dc.relation.journalvolume | 22 | en_US |
dc.relation.journalissue | 11 | en_US |
item.cerifentitytype | Publications | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.fulltext | no fulltext | - |
item.grantfulltext | none | - |
item.languageiso639-1 | English | - |
crisitem.author.dept | College of Life Sciences | - |
crisitem.author.dept | Department of Bioscience and Biotechnology | - |
crisitem.author.dept | National Taiwan Ocean University,NTOU | - |
crisitem.author.dept | Bachelor Degree Program in Marine Biotechnology | - |
crisitem.author.dept | Center of Excellence for the Oceans | - |
crisitem.author.dept | College of Life Sciences | - |
crisitem.author.dept | Department of Bioscience and Biotechnology | - |
crisitem.author.dept | National Taiwan Ocean University,NTOU | - |
crisitem.author.dept | Center of Excellence for the Oceans | - |
crisitem.author.orcid | 0000-0002-4929-6573 | - |
crisitem.author.orcid | 0000-0002-0363-1129 | - |
crisitem.author.parentorg | National Taiwan Ocean University,NTOU | - |
crisitem.author.parentorg | College of Life Sciences | - |
crisitem.author.parentorg | College of Life Sciences | - |
crisitem.author.parentorg | National Taiwan Ocean University,NTOU | - |
crisitem.author.parentorg | National Taiwan Ocean University,NTOU | - |
crisitem.author.parentorg | College of Life Sciences | - |
crisitem.author.parentorg | National Taiwan Ocean University,NTOU | - |
Appears in Collections: | 生命科學暨生物科技學系 |
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