http://scholars.ntou.edu.tw/handle/123456789/20093
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Po-Tsang Lee | en_US |
dc.contributor.author | S Bird | en_US |
dc.contributor.author | J Zou | en_US |
dc.contributor.author | S A M Martin | en_US |
dc.date.accessioned | 2022-01-21T07:29:43Z | - |
dc.date.available | 2022-01-21T07:29:43Z | - |
dc.date.issued | 2017-06 | - |
dc.identifier.issn | 1050-4648 | - |
dc.identifier.uri | http://scholars.ntou.edu.tw/handle/123456789/20093 | - |
dc.description.abstract | The acute phase response (APR) is an early innate immune function that is initiated by inflammatory signals, leading to the release of acute phase proteins to the bloodstream to re-establish homeostasis following microbial infection. In this study we analysed the Atlantic salmon (Salmo salar) whole-genome database and identified five C-reactive protein (CRP)/serum amyloid P component (SAP) like molecules namely CRP/SAP-1a, CRP/SAP-1b, CRP/SAP-1c, CRP/SAP-2 and CRP/SAP-3. These CRP/SAP genes formed two distinct sub-families, a universal group (group I) present in all vertebrates and a fish/amphibian specific group (group II). Salmon CRP/SAP-1a, CRP/SAP-1b and CRP/SAP-1c and CRP/SAP-2 belong to the group I family whilst salmon CRP/SAP-3 is a member of group II. Gene expression analysis showed that the salmon CRP/SAP-1a as well as serum amyloid A-5 (SAA-5), one of the major acute phase proteins, were significantly up-regulated by recombinant cytokines (rIL-1β and rIFNγ) in primary head kidney cells whilst the other four CRP/SAPs remained refractory. Furthermore, SAA-5 was produced as the main acute phase protein (APP) in Atlantic salmon challenged with Aeromonas salmonicida (aroA(-) strain) whilst salmon CRP/SAPs remained unaltered. Overall, these data illustrate the potential different functions of expanded salmon CRP/SAPs to their mammalian homologues. | en_US |
dc.language.iso | en | en_US |
dc.publisher | PubMed | en_US |
dc.relation.ispartof | Fish and Shellfish Immunology | en_US |
dc.subject | Acute phase protein | en_US |
dc.subject | Atlantic salmon | en_US |
dc.subject | C-reactive protein | en_US |
dc.subject | Gene expression | en_US |
dc.subject | Innate immunity | en_US |
dc.subject | Serum amyloid-P | en_US |
dc.title | Phylogeny and expression analysis of C-reactive protein (CRP) and serum amyloid-P (SAP) like genes reveal two distinct groups in fish | en_US |
dc.type | journal article | en_US |
dc.identifier.doi | https://doi.org/10.1016/j.fsi.2017.03.037 | - |
dc.relation.journalvolume | 65 | en_US |
dc.relation.pages | 42-51 | en_US |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.languageiso639-1 | en | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | College of Life Sciences | - |
crisitem.author.dept | Department of Aquaculture | - |
crisitem.author.dept | National Taiwan Ocean University,NTOU | - |
crisitem.author.orcid | https://orcid.org/ 0000-0003-3657-2599 | - |
crisitem.author.parentorg | National Taiwan Ocean University,NTOU | - |
crisitem.author.parentorg | College of Life Sciences | - |
顯示於: | 水產養殖學系 |
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