http://scholars.ntou.edu.tw/handle/123456789/20760
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Chang, Yi-Cheng | en_US |
dc.contributor.author | Pai, Chih-Yu | en_US |
dc.contributor.author | Chen, Yi-Chih | en_US |
dc.contributor.author | Ting, Hsiu-Chi | en_US |
dc.contributor.author | Martinez, Pedro | en_US |
dc.contributor.author | Telford, Maximilian J. | en_US |
dc.contributor.author | Yu, Jr-Kai | en_US |
dc.contributor.author | Su, Yi-Hsien | en_US |
dc.date.accessioned | 2022-02-17T05:29:21Z | - |
dc.date.available | 2022-02-17T05:29:21Z | - |
dc.date.issued | 2016-02-1 | - |
dc.identifier.issn | 0012-1606 | - |
dc.identifier.uri | http://scholars.ntou.edu.tw/handle/123456789/20760 | - |
dc.description.abstract | The spatially opposed expression of Antidorsalizing morphogenetic protein (Admp) and BMP signals controls dorsoventral (DV) polarity across Bilateria and hence represents an ancient regulatory circuit. Here, we show that in addition to the conserved admp1 that constitutes the ancient circuit, a second admp gene (admp2) is present in Ambulacraria (Echinodermata+Hemichordata) and two marine worms belonging to Xenoturbellida and Acoelomorpha. The phylogenetic distribution implies that the two admp genes were duplicated in the Bilaterian common ancestor and admp2 was subsequently lost in chordates and protostomes. We show that the ambulacrarian admp1 and admp2 are under opposite transcriptional control by BMP signals and knockdown of Admps in sea urchins impaired their DV polarity. Over-expression of either Admps reinforced BMP signaling but resulted in different phenotypes in the sea urchin embryo. Our study provides an excellent example of signaling circuit rewiring and protein functional changes after gene duplications. (C) 2015 Elsevier Inc. All rights reserved. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | en_US |
dc.relation.ispartof | DEV BIOL | en_US |
dc.subject | INDIRECT DEVELOPING HEMICHORDATE | en_US |
dc.subject | SEA-URCHIN EMBRYO | en_US |
dc.subject | EXPRESSION | en_US |
dc.subject | CHORDIN | en_US |
dc.subject | ORGANIZER | en_US |
dc.subject | PATHWAYS | en_US |
dc.subject | FATES | en_US |
dc.subject | SIZE | en_US |
dc.subject | BMPS | en_US |
dc.title | Regulatory circuit rewiring and functional divergence of the duplicate admp genes in dorsoventral axial patterning | en_US |
dc.type | journal article | en_US |
dc.identifier.doi | 10.1016/j.ydbio.2015.12.015 | - |
dc.identifier.isi | WOS:000369124700010 | - |
dc.relation.journalvolume | 410 | en_US |
dc.relation.journalissue | 1 | en_US |
dc.relation.pages | 108-118 | en_US |
item.grantfulltext | none | - |
item.fulltext | no fulltext | - |
item.languageiso639-1 | en_US | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.cerifentitytype | Publications | - |
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