http://scholars.ntou.edu.tw/handle/123456789/23109
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Wei, Yu-Jyun | en_US |
dc.contributor.author | Fang, Rui-En | en_US |
dc.contributor.author | Ou, Jing-Yi | en_US |
dc.contributor.author | Pan, Chorng-Liang | en_US |
dc.contributor.author | Huang, Chung-Hsiung | en_US |
dc.date.accessioned | 2022-11-15T00:41:12Z | - |
dc.date.available | 2022-11-15T00:41:12Z | - |
dc.date.issued | 2022-09-01 | - |
dc.identifier.issn | 1756-4646 | - |
dc.identifier.uri | http://scholars.ntou.edu.tw/handle/123456789/23109 | - |
dc.description.abstract | Although recent studies indicated the immune modulatory effects of Porphyra extract and derived poly-saccharides, the impact of Porphyra-derived oligosaccharides on immune responses remains unclear. This study aimed to explore the influence of Porphyra-derived polysaccharides (PP), oligosaccharides (PO) and the PO/PP mixture on antigen-specific immune responses in ovalbumin (OVA)-sensitized mice. Daily treatment with PP, PO, or PO/PP mixture did not influence the body weight, spleen weight index, serum levels of total and OVA-specific IgG. However, the levels of IgG1, IgG2a, total and OVA-specific IgE were down-regulated. Furthermore, pro-ductions of IL-2, IFN-gamma, IL-4, and IL17 from splenocytes were diminished in mice treated with PP, PO, and PO/PP mixture. In contrast, the secretion of IL-10 was slightly increased and the ratio of IL-10/IL-4 was markedly raised. These results demonstrated the modulatory effects of PP, PO, and PO/PP mixture on antigen-specific immune responses, revealing their potential to be developed as functional foods for immunomodulation. | en_US |
dc.language.iso | English | en_US |
dc.publisher | ELSEVIER | en_US |
dc.relation.ispartof | JOURNAL OF FUNCTIONAL FOODS | en_US |
dc.subject | Antigen-specific immune response | en_US |
dc.subject | Oligosaccharides | en_US |
dc.subject | Polysaccharides | en_US |
dc.subject | Porphyra | en_US |
dc.subject | T-cell immunity | en_US |
dc.title | Modulatory effects of Porphyra-derived polysaccharides, oligosaccharides and their mixture on antigen-specific immune responses in ovalbumin-sensitized mice | en_US |
dc.type | journal article | en_US |
dc.identifier.doi | 10.1016/j.jff.2022.105209 | - |
dc.identifier.isi | WOS:000862694200002 | - |
dc.relation.journalvolume | 96 | en_US |
dc.identifier.eissn | 2214-9414 | - |
item.cerifentitytype | Publications | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.fulltext | no fulltext | - |
item.grantfulltext | none | - |
item.languageiso639-1 | English | - |
crisitem.author.dept | College of Life Sciences | - |
crisitem.author.dept | Department of Food Science | - |
crisitem.author.dept | National Taiwan Ocean University,NTOU | - |
crisitem.author.dept | College of Life Sciences | - |
crisitem.author.dept | Department of Food Science | - |
crisitem.author.dept | National Taiwan Ocean University,NTOU | - |
crisitem.author.orcid | 0000-0002-5232-1717 | - |
crisitem.author.orcid | 0000-0002-2295-6412 | - |
crisitem.author.parentorg | National Taiwan Ocean University,NTOU | - |
crisitem.author.parentorg | College of Life Sciences | - |
crisitem.author.parentorg | National Taiwan Ocean University,NTOU | - |
crisitem.author.parentorg | College of Life Sciences | - |
顯示於: | 食品科學系 |
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