http://scholars.ntou.edu.tw/handle/123456789/23791
Title: | Carnosic Acid Alleviates Levodopa-Induced Dyskinesia and Cell Death in 6-Hydroxydopamine-lesioned Rats and in SH-SY5Y Cells |
Authors: | Lai, Chun-Yi Lin, Chia-Yuan Wu, Chi-Rei Tsai, Chon-Haw Tsai, Chia-Wen |
Keywords: | 6-hydroxydopamine;DARPP-32/ΔFosB;ERK1/2-c-jun;carnosic acid;levodopa-induced dyskinesia |
Issue Date: | Aug-2021 |
Publisher: | FRONTIERS MEDIA SA |
Journal Volume: | 12 |
Source: | Frontiers in pharmacology |
Abstract: | The present study investigated the impact of carnosic acid (CA) from rosemary on the levodopa (L-dopa)-induced dyskinesia (LID) in rats treated with 6-hydroxydopamine (6-OHDA). To establish the model of LID, 6-OHDA-lesioned rats were injected intraperitoneally with 30 mg/kg L-dopa once a day for 36 days. Rats were daily administrated with 3 or 15 mg/kg CA by oral intubation prior to... |
URI: | http://scholars.ntou.edu.tw/handle/123456789/23791 |
ISSN: | 1663-9812 |
DOI: | 10.3389/fphar.2021.703894 |
Appears in Collections: | 食品科學系 |
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