http://scholars.ntou.edu.tw/handle/123456789/3589
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Sen-Wei Tsai | en_US |
dc.contributor.author | Chi-Chien Lin | en_US |
dc.contributor.author | Shih-Chao Lin | en_US |
dc.contributor.author | Shun-Ping Wang | en_US |
dc.contributor.author | Deng-Ho Yang | en_US |
dc.date.accessioned | 2020-11-18T08:15:34Z | - |
dc.date.available | 2020-11-18T08:15:34Z | - |
dc.date.issued | 2019-07 | - |
dc.identifier.issn | 0892-3973 | - |
dc.identifier.uri | http://scholars.ntou.edu.tw/handle/123456789/3589 | - |
dc.description.abstract | Context: Osteoarthritis (OA) is a degenerative joint disease with damage to the articular cartilage. Active production of inflammatory cytokine/chemokine and matrix metalloproteinases may be found during the progression of OA. Isorhamnetin had the effects of anti-inflammatory, antioxidant, anti-ischemia, anti-atherosclerotic hepatoprotective and anticancer activities. Objective: Our study was focused on the effects of isorhamnetin treatment in OA. Materials and methods: We used monosodium iodoacetate (MIA)-induced OA rats to evaluate the effects of isorhamnetin related anti-inflammatory process. The rats in all groups were sacrificed on four weeks post-MIA injection. The measurements of knee joint swelling, histological analysis, serum inflammatory biomarkers and western blot were evaluated. Results: We found that isorhamnetin may reduce MIA-induced knee swelling by significantly reduction of articular cartilage damage.in rats. Suppression of pro-inflammatory cytokines production was found after isohamnetin treatment. Isorhamnetin inhibited the production of NO and PGE2, and the expression of iNOS and COX-2. The production of COMP, CTX-II and osteopontin (OPN) were also inhibited in MIA-induced OA rats. Discussion and conclusions: Isorhamnetin may modulate the inflammatory progression of OA in MIA-induced OA rats. The prevention of cartilage damage was found in OA after adequate isorhamnetin treatment. Isorhamnetin may serve as a potential agent for the management of OA. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Taylor & Francis | en_US |
dc.relation.ispartof | Immunopharmacology and Immunotoxicology | en_US |
dc.subject | Isorhamnetin | en_US |
dc.subject | anti-inflammatory | en_US |
dc.subject | osteoarthritis | en_US |
dc.subject | arthritis | en_US |
dc.subject | monosodium iodoacetate-induced osteoarthritis | en_US |
dc.title | Isorhamnetin ameliorates inflammatory responses and articular cartilage damage in the rats of monosodium iodoacetate-induced osteoarthritis | en_US |
dc.type | journal article | en_US |
dc.identifier.doi | 10.1080/08923973.2019.1641723 | - |
dc.identifier.isi | 000479429200001 | - |
dc.relation.journalvolume | 41 | en_US |
dc.relation.journalissue | 4 | en_US |
item.openairetype | journal article | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | none | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | College of Life Sciences | - |
crisitem.author.dept | Bachelor Degree Program in Marine Biotechnology | - |
crisitem.author.dept | National Taiwan Ocean University,NTOU | - |
crisitem.author.orcid | 0000-0003-2942-5937 | - |
crisitem.author.parentorg | National Taiwan Ocean University,NTOU | - |
crisitem.author.parentorg | College of Life Sciences | - |
顯示於: | 海洋生物科技學士學位學程(系) |
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