http://scholars.ntou.edu.tw/handle/123456789/3738
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Sheng, Wanqiang | en_US |
dc.contributor.author | LaFleur, Martin W. | en_US |
dc.contributor.author | Nguyen, Thao H. | en_US |
dc.contributor.author | Chen, Sujun | en_US |
dc.contributor.author | Chakravarthy, Ankur | en_US |
dc.contributor.author | Conway, Jake Ryan | en_US |
dc.contributor.author | Li, Ying | en_US |
dc.contributor.author | Chen, Hao | en_US |
dc.contributor.author | Yang, Henry | en_US |
dc.contributor.author | Hsu, Pang-Hung | en_US |
dc.contributor.author | Van Allen, Eliezer M. | en_US |
dc.contributor.author | Freeman, Gordon J. | en_US |
dc.contributor.author | De Carvalho, Daniel D. | en_US |
dc.contributor.author | He, Housheng Hansen | en_US |
dc.contributor.author | Sharpe, Arlene H. | en_US |
dc.contributor.author | Shi, Yang | en_US |
dc.date.accessioned | 2020-11-18T09:30:08Z | - |
dc.date.available | 2020-11-18T09:30:08Z | - |
dc.date.issued | 2018-07-26 | - |
dc.identifier.issn | 0092-8674 | - |
dc.identifier.uri | http://scholars.ntou.edu.tw/handle/123456789/3738 | - |
dc.description.abstract | Chromatin regulators play a broad role in regulating gene expression and, when gone awry, can lead to cancer. Here, we demonstrate that ablation of the histone demethylase LSD1 in cancer cells increases repetitive element expression, including endogenous retroviral elements (ERVs), and decreases expression of RNA-induced silencing complex (RISC) components. Significantly, this leads to double-stranded RNA (dsRNA) stress and activation of type 1 interferon, which stimulates anti-tumor T cell immunity and restrains tumor growth. Furthermore, LSD1 depletion enhances tumor immunogenicity and T cell infiltration in poorly immunogenic tumors and elicits significant responses of checkpoint blockade-refractory mouse melanoma to anti-PD-1 therapy. Consistently, TCGA data analysis shows an inverse correlation between LSD1 expression and CD8(+) T cell infiltration in various human cancers. Our study identifies LSD1 as a potent inhibitor of antitumor immunity and responsiveness to immunotherapy and suggests LSD1 inhibition combined with PD-(L)1 blockade as a novel cancer treatment strategy. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | CELL PRESS | en_US |
dc.relation.ispartof | CELL | en_US |
dc.subject | ENDOGENOUS RETROVIRUSES | en_US |
dc.subject | DNA METHYLATION | en_US |
dc.subject | CANCER-CELLS | en_US |
dc.subject | T-CELLS | en_US |
dc.subject | PD-1 | en_US |
dc.subject | THERAPY | en_US |
dc.subject | TUMORS | en_US |
dc.subject | IMMUNOTHERAPY | en_US |
dc.subject | DEMETHYLATION | en_US |
dc.subject | SENSITIVITY | en_US |
dc.title | LSD1 Ablation Stimulates Anti-tumor Immunity and Enables Checkpoint Blockade | en_US |
dc.type | journal article | en_US |
dc.identifier.doi | 10.1016/j.cell.2018.05.052 | - |
dc.identifier.isi | WOS:000439870500007 | - |
dc.identifier.url | <Go to ISI>://WOS:000439870500007 | |
dc.relation.journalvolume | 174 | en_US |
dc.relation.journalissue | 3 | en_US |
dc.relation.pages | 549-+ | en_US |
item.fulltext | no fulltext | - |
item.languageiso639-1 | en_US | - |
item.grantfulltext | none | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | College of Life Sciences | - |
crisitem.author.dept | Department of Bioscience and Biotechnology | - |
crisitem.author.dept | National Taiwan Ocean University,NTOU | - |
crisitem.author.dept | Bachelor Degree Program in Marine Biotechnology | - |
crisitem.author.orcid | 0000-0001-6873-6434 | - |
crisitem.author.parentorg | National Taiwan Ocean University,NTOU | - |
crisitem.author.parentorg | College of Life Sciences | - |
crisitem.author.parentorg | College of Life Sciences | - |
顯示於: | 海洋生物科技學士學位學程(系) 生命科學暨生物科技學系 03 GOOD HEALTH AND WELL-BEING |
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