http://scholars.ntou.edu.tw/handle/123456789/5335
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Lin, Yi-Chen | en_US |
dc.contributor.author | Wu, Chang-Yi | en_US |
dc.contributor.author | Hu, Chin-Hwa | en_US |
dc.contributor.author | Pai, Tun-Wen | en_US |
dc.contributor.author | Chen, Yet-Ran | en_US |
dc.contributor.author | Wang, Wen-Der | en_US |
dc.date.accessioned | 2020-11-19T09:42:09Z | - |
dc.date.available | 2020-11-19T09:42:09Z | - |
dc.date.issued | 2020-08 | - |
dc.identifier.issn | 2076-3921 | - |
dc.identifier.uri | http://scholars.ntou.edu.tw/handle/123456789/5335 | - |
dc.description.abstract | Benzo[a]pyrene (B[a]P) is a polycyclic aromatic hydrocarbon formed by the incomplete combustion of organic matter. Environmental B[a]P contamination poses a serious health risk to many organisms because the pollutant may negatively affect many physiological systems. As such, chronic exposure to B[a]P is known to lead to locomotor dysfunction and neurodegeneration in several organisms. In this study, we used the zebrafish model to delineate the acute toxic effects of B[a]P on the developing nervous system. We found that embryonic exposure of B[a]P downregulatesshhandisl1, causing morphological hypoplasia in the telencephalon, ventral thalamus, hypothalamus, epiphysis and posterior commissure. Moreover, hypoxia-inducible factors (hif1aandhif2a) are repressed upon embryonic exposure of B[a]P, leading to reduced expression of the Hif-target genes,epoandsurvivin, which are associated with neural differentiation and maintenance. During normal embryogenesis, low-level oxidative stress regulates neuronal development and function. However, our experiments revealed that embryonic oxidative stress is greatly increased in B[a]P-treated embryos. The expression ofcatalasewas decreased andsod1expression increased in B[a]P-treated embryos. These transcriptional changes were coincident with increased embryonic levels of H(2)O(2)and malondialdehyde, with the levels in B[a]P-treated fish similar to those in embryos treated with 120-mu M H2O2. Together, our data suggest that reduced Hif signaling and increased oxidative stress are involved in B[a]P-induced acute neurotoxicity during embryogenesis. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | MDPI | en_US |
dc.relation.ispartof | ANTIOXIDANTS-BASEL | en_US |
dc.subject | POLYCYCLIC AROMATIC-HYDROCARBONS | en_US |
dc.subject | EARLY ADOLESCENCE PERIOD | en_US |
dc.subject | HYDROGEN-PEROXIDE | en_US |
dc.subject | LIPID-PEROXIDATION | en_US |
dc.subject | NEURAL INDUCTION | en_US |
dc.subject | RETINOIC ACID | en_US |
dc.subject | DNA-DAMAGE | en_US |
dc.subject | EXPRESSION | en_US |
dc.subject | GENE | en_US |
dc.subject | EXPOSURE | en_US |
dc.title | Integrated Hypoxia Signaling and Oxidative Stress in Developmental Neurotoxicity of Benzo[a]Pyrene in Zebrafish Embryos | en_US |
dc.type | journal article | en_US |
dc.identifier.doi | 10.3390/antiox9080731 | - |
dc.identifier.isi | WOS:000564869600001 | - |
dc.identifier.url | <Go to ISI>://WOS:000564869600001 | |
dc.relation.journalvolume | 9 | en_US |
dc.relation.journalissue | 8 | en_US |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.fulltext | no fulltext | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en_US | - |
crisitem.author.dept | College of Life Sciences | - |
crisitem.author.dept | Department of Bioscience and Biotechnology | - |
crisitem.author.dept | National Taiwan Ocean University,NTOU | - |
crisitem.author.dept | Doctoral Degree Program in Marine Biotechnology | - |
crisitem.author.orcid | 0000-0001-9582-2303 | - |
crisitem.author.parentorg | National Taiwan Ocean University,NTOU | - |
crisitem.author.parentorg | College of Life Sciences | - |
crisitem.author.parentorg | College of Life Sciences | - |
顯示於: | 生命科學暨生物科技學系 03 GOOD HEALTH AND WELL-BEING 資訊工程學系 11 SUSTAINABLE CITIES & COMMUNITIES |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。