http://scholars.ntou.edu.tw/handle/123456789/5894
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Chen, Cheng-Hsien | en_US |
dc.contributor.author | Sue, Yuh-Mou | en_US |
dc.contributor.author | Cheng, Chung-Yi | en_US |
dc.contributor.author | Chen, Yen-Cheng | en_US |
dc.contributor.author | Liu, Chung-Te | en_US |
dc.contributor.author | Hsu, Yung-Ho | en_US |
dc.contributor.author | Hwang, Pai-An | en_US |
dc.contributor.author | Huang, Nai-Jen | en_US |
dc.contributor.author | Chen, Tso-Hsiao | en_US |
dc.date.accessioned | 2020-11-19T11:17:43Z | - |
dc.date.available | 2020-11-19T11:17:43Z | - |
dc.date.issued | 2017-01-18 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | http://scholars.ntou.edu.tw/handle/123456789/5894 | - |
dc.description.abstract | Tubulointerstitial fibrosis is recognized as a key determinant of progressive chronic kidney disease (CKD). Fucoidan, a sulphated polysaccharide extracted from brown seaweed, exerts beneficial effects in some nephropathy models. The present study evaluated the inhibitory effect of oligo-fucoidan (800 Da) on renal tubulointerstitial fibrosis. We established a mouse CKD model by right nephrectomy with transient ischemic injury to the left kidney. Six weeks after the surgery, we fed the CKD mice oligo-fucoidan at 10, 20, and 100 mg/kg/d for 6 weeks and found that the oligo-fucoidan doses less than 100 mg/kg/d improved renal function and reduced renal tubulointerstitial fibrosis in CKD mice. Oligo-fucoidan also inhibited pressure-induced fibrotic responses and the expression of CD44, beta-catenin, and TGF-beta in rat renal tubular cells (NRK-52E). CD44 knockdown downregulated the expression of beta-catenin and TGF-beta in pressure-treated cells. Additional ligands for CD44 reduced the anti-fibrotic effect of oligo-fucoidan in NRK-52E cells. These data suggest that oligo-fucoidan at the particular dose prevents renal tubulointerstitial fibrosis in a CKD model. The anti-fibrotic effect of oligo-fucoidan may result from interfering with the interaction between CD44 and its extracellular ligands. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | NATURE PUBLISHING GROUP | en_US |
dc.relation.ispartof | SCI REP-UK | en_US |
dc.subject | MOLECULAR-WEIGHT FUCOIDAN | en_US |
dc.subject | OBSTRUCTIVE NEPHROPATHY | en_US |
dc.subject | IN-VIVO | en_US |
dc.subject | ISCHEMIA/REPERFUSION INJURY | en_US |
dc.subject | SULFATED POLYSACCHARIDES | en_US |
dc.subject | MESENCHYMAL TRANSITION | en_US |
dc.subject | INTERSTITIAL FIBROSIS | en_US |
dc.subject | DIABETIC-NEPHROPATHY | en_US |
dc.subject | URETERAL OBSTRUCTION | en_US |
dc.subject | UNDARIA-PINNATIFIDA | en_US |
dc.title | Oligo-fucoidan prevents renal tubulointerstitial fibrosis by inhibiting the CD44 signal pathway | en_US |
dc.type | journal article | en_US |
dc.identifier.doi | 10.1038/srep40183 | - |
dc.identifier.isi | WOS:000392172400001 | - |
dc.identifier.url | <Go to ISI>://WOS:000392172400001 | |
dc.relation.journalvolume | 7 | en_US |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.fulltext | no fulltext | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en_US | - |
crisitem.author.dept | College of Life Sciences | - |
crisitem.author.dept | Department of Bioscience and Biotechnology | - |
crisitem.author.dept | National Taiwan Ocean University,NTOU | - |
crisitem.author.dept | Bachelor Degree Program in Marine Biotechnology | - |
crisitem.author.orcid | 0000-0002-9317-2754 | - |
crisitem.author.parentorg | National Taiwan Ocean University,NTOU | - |
crisitem.author.parentorg | College of Life Sciences | - |
crisitem.author.parentorg | College of Life Sciences | - |
顯示於: | 生命科學暨生物科技學系 03 GOOD HEALTH AND WELL-BEING |
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