Development and Effectiveness of Vaccine against Grouper Iridovirus of Taiwan

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基本資料

Project title

Code/計畫編號

91農科-3.1.1-漁-F1(15)

Translated Name/計畫中文名

台灣石斑虹彩病毒疫苗之開發與效果評估

Project Coordinator/計畫主持人

Hsin-Yiu Chou

Funding Organization/主管機關

Council of Agriculture,Executive Yuan

Department/Unit

Department of Aquaculture

Website

https://www.grb.gov.tw/search/planDetail?id=941290

Year

2002

Start date/計畫起

01-01-2002

Expected Completion/計畫迄

31-12-2002

Bugetid/研究經費

533千元

ResearchField/研究領域

生物技術(農)
漁業

"魚類病毒性疫苗的研發已超過二十年的時間，但是除了IPNV的重組DNA疫苗外，並無商品化產品被使用在水產養殖的魚病防治上。近年來由於許多研究人員努力，數種重要魚類病毒的疫苗在實驗室被成功開發出，但要成為商業化產品仍有許多困難。石斑虹彩病毒 (TGIV) 在1995年分離自本省罹病石斑魚，其高病原性和廣寄主範圍，對本省海水魚養殖產業具有潛在威脅。本研究室為了有效增殖台灣石斑虹彩病毒因此建立了石斑泳鰾細胞株，且預備實驗之結果顯示利用此細胞所製備之石斑虹彩病毒之不活化疫苗具有保護效果。本計劃擬進一步探討不活化與弱毒化疫苗的開發研究，並由保護效果評估利用疫苗防治此感染症之可行性。" "Fish viral vaccines have been in development for over 20 years. Unfortunately, with the exception of the recombinant DNA vaccine for IPNV (infectious pancreatic necrosis virus) sold by Norbio (Internet), there are no commercially available vaccines for fish viral pathogens in aquaculture. Recently, efforts of a number of laboratories have successfully developed some vaccines against important viral diseases for fish under controlled laboratory conditions. However, many problems are still remaining in the development of commercially available viral vaccine. Grouper iridovirus of Taiwan (TGIV) was isolated from moribund grouper in 1995, due to its virulence and broad host range; the potential menace of this iridovirus to marine aquaculture industry is undoubtedly. A more effective culture system has established in our laboratory and informal pilot studies showed that vaccination of formalin-killed virus protected groupers from TGIV challenge test. Therefore, attempts were made to develop inactivated and attenuated vaccines against iridoviral infection, and assay the effectiveness in this project."

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Development and Effectiveness of Vaccine against Grouper Iridovirus of Taiwan

基本資料

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