Development of Oral Vaccine against Grouper Iridovirus of Taiwan

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基本資料

Project title

Code/計畫編號

93農科-4.1.7-漁-F1(6)

Translated Name/計畫中文名

石斑虹彩病毒口服疫苗之開發研究

Project Coordinator/計畫主持人

Hsin-Yiu Chou

Funding Organization/主管機關

Council of Agriculture,Executive Yuan

Department/Unit

Department of Aquaculture

Website

https://www.grb.gov.tw/search/planDetail?id=968705

Year

2004

Start date/計畫起

01-01-2004

Expected Completion/計畫迄

31-12-2004

Bugetid/研究經費

600千元

ResearchField/研究領域

生物技術(農)
漁業

"疫苗開發雖是解決魚類病毒性疾病的重要防治對策之一，但如成本偏高、施用方式的選擇、以及緊迫與有效性等問題仍待解決，因此目前只有極少數的疫苗成為商品化。本研究室針對台灣石斑虹彩病毒(grouper iridovirus of Taiwan，簡稱TGIV)發展出具100%保護效果之不活化疫苗，但是注射免疫不僅會對魚體造成緊迫，養殖現場施用不易，本年度希望進一步利用微膠囊包埋技術，將TGIV不活化疫苗製備為奈米疫苗，讓疫苗可以穩定通過魚體的胃腸道，同時探討輔助飼料對魚體抗病能力之影響後，添加輔助飼料強化疫苗的保護效果，製備出具良好保護效果之虹彩病毒口服疫苗。" "Vaccine development is one of the major approaches of controlling viral diseases in aquaculture. Unfortunately, in consideration of detailed items of vaccination, such as cost, stress and efficacy, there are only a few of commercially available vaccines for fish viral pathogens to date. In our previous studies, inactivated vaccines was developed against grouper iridovirus of Taiwan (TGIV), and a 100% protection rate was obtained via injection vaccination under challenge tests. However, injection vaccination is considerably time-consuming and labor-intensive. To aim at practical uses of the TGIV vaccine, oral vaccination is claim attention in this project. First, for better protection of viral antigens through gastrointestinal tract of fish, encapsulated treatment is considered. Moreover, in combination of vaccine and dietary supplementation may be effective mean of increasing potency of vaccine to resist viral infection. Therefore, present study will conduct to develop encapsulated oral vaccine for practicable use of TGIV vaccine and control of the disease."

DSpace CRIS

Development of Oral Vaccine against Grouper Iridovirus of Taiwan

基本資料

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