The Development of a Multi-Angle Incident Light and Multi-Point Measurement Phase Image Interrogation Surface Plasmon Resonance System

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簡歷

基本資料

Project title

Code/計畫編號

MOST103-2221-E019-031

Translated Name/計畫中文名

小範圍多角度多點影像量測式相位調制表面電漿子共振系統之開發

Project Coordinator/計畫主持人

Shu-Sheng Lee

Funding Organization/主管機關

National Science and Technology Council

Department/Unit

Department of Systems Engineering and Naval Architecture

Website

https://www.grb.gov.tw/search/planDetail?id=8361183

Year

2014

Start date/計畫起

01-08-2014

Expected Completion/計畫迄

01-07-2015

Bugetid/研究經費

777千元

ResearchField/研究領域

醫學工程

生活科技及醫療的進步，延長人類的平均壽命，也增進人們對自身健康的重視。生醫檢測技術在醫療中提供求診人的身體狀態相關訊息，在促進人類的醫療水準提升佔相當重要的角色，因此生醫檢測的相關技術仍是全球研發人員致力發展的目標。本研究計畫即是針對可應用於生醫分子反應檢測開發一套「小範圍多角度多點影像量測式相位調制表面電漿子共振系統」。有鑑於研究團隊過去開發的表面電漿子共振系統均為單點式量測，在實際應用上不符合生物醫學要求的同時量測反應組及對照組兩個樣本需求，因此在本計畫中將修改以往點聚焦的光路設計，改為聚焦成直線的形式，可於聚焦線上同時量測多個反應點。另外嘗試使用目前較少人採取的量測機制：將量測光以多角度入射與相位調制技術整合，在系統上以擴束鏡將光源光束直徑，使入射量測點的聚焦線可達成小範圍多角度的入射狀態，達到引入多角度量測的因素至相位偵測技術，提供更多的相位資訊進行量測樣本的相位變化運算，增加整體系統量測精度及解析度。本計畫另一重點為嘗試採用奈米金屬孔洞的晶片基板設計，利用其適用於表面電漿子共振及 TM 穿透光譜之特性，在於本系統中引入多波長的穿透光譜量測，經由交叉量測比對達到更穩定的量測結果。 "The progresses of the technology and the medical treatment extend the life expectancy of human and also evoke the awareness of health care ourselves. The report of the biomedical detection results provides lot of information about the health condition of the patient. It plays a very important role in facilitate the progress of the medical treatment. Therefore, the related biomedical detection technologies are still the significant research topics for researchers in the world. The goal of this project is to develop a multi-angle incident light and multi-point measurement phase image interrogation surface plasmon resonance system which is expected to the bio-medical molecular interaction measurement. The previous developed system of our research team could perform single point detection and didn’t exactly meet the requirement of the biomedical measurement because there should be a control reaction accompanied with the testing one. To improve this, the system proposed here will replace the focus light spot by the focus light line and multi-points reactions can be detected simultaneously. Besides, multi-angle incident light with the small dynamic range will be introduced and to provide additional phase difference data. To realize this design, the light beam will be expanded by a beam expander and then be focused into a line by the cylindrical elliptic reflective mirror. Hence, the incident line light will possess multi incident angle to the sample. This will increase the measurement sensitivity and resolution of the whole SPR system. In addition, the metallic nano-structures substrate will also be integrated into the system because it is suitable for SPR measurement and TM transverse spectrum measurement. The TM transverse spectrum obtained by the transmission sampling light can provided the cross check of the SPR detecting result and to enhance more reliability of our system."

Keyword(s)

表面電漿子共振
多角度入射
奈米金屬孔洞
相位調制
時進正交相移法
TM 穿透光譜系統
Surface Plasmon Resonance
Multi-angle Incident Light
Metallic Nano-structures
Phase Modulation
Time-stepping Quadrature Phase Shifting Method
TM Transverse Spectrum Measurement System

DSpace CRIS

The Development of a Multi-Angle Incident Light and Multi-Point Measurement Phase Image Interrogation Surface Plasmon Resonance System

基本資料

Description