Preparation Multifunctional Mesoporous Silica Nanoparticle

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基本資料

Project title

Code/計畫編號

NSC102-2113-M019-002

Translated Name/計畫中文名

製備多功能中孔二氧化矽奈米粒子

Project Coordinator/計畫主持人

Hsiu-Mei Lin

Funding Organization/主管機關

National Science and Technology Council

Department/Unit

Department of Bioscience and Biotechnology

Website

https://www.grb.gov.tw/search/planDetail?id=3098943

Year

2013

Start date/計畫起

01-08-2013

Expected Completion/計畫迄

31-07-2014

Bugetid/研究經費

1200千元

ResearchField/研究領域

化學

"奈米粒子顯影劑因在生醫成像及治療診斷學上的多種應用而備受重視。近年來，科學家們對於以多功能二氧化矽奈米粒子(mesoporous silica nanoparticles, MSN)在成像及治療上的雙效應用展現出明顯的研究興趣。這個領域迅速擴展，產生出一個新的術語：「治療診斷學」(syn: theranostic)，這個術語是用來形容作為診斷和治療劑的雙重角色的平台。與傳統慣用的顯影劑相比，二氧化矽奈米粒子擁有多種潛在優勢，此奈米粒子能夠經由設計合成出多功能二氧化矽奈米粒子，希望改善細胞內檢測的靈敏度且能增強標靶的效率。在此項研究中，我們將合成出以雙重顯像、細胞內控制及葉酸修飾同時具有治療與診斷多功能中孔二氧化矽奈米粒子，希望此多功能的二氧化矽奈米粒子應用在生醫成像及治療診斷學，這種組合的多功能二氧化矽奈米粒子能夠同時在患部累積足夠的劑量當作顯影劑及治療藥劑，使它們在治療診斷學上大有可為。在此研究中，我們將進行兩個部分的研究。首先，是同時參雜Eu3+與Gd3+進入MSN 孔壁中，合成出EuGd-MSN，使MSN具有螢光與磁性的顯影雙功能；第二部分以 EuGd-MSN奈米粒子為基礎，將細胞內控制釋放的藥物嫁接上EuGd-MSN的孔壁上；最後將於EuGd-MSN/藥物奈米粒子表面修飾上葉酸分子，根據之前的研究經驗以最佳化條件來結合雙重顯影、細胞內控制與葉酸三者到中孔洞二氧化矽奈米粒子上，置備出多功能中孔洞二氧化矽奈米粒子EuGd-MSN/藥物/葉酸並探討其物性、化性，進行in vitro和in vivo的測試。" "The use of nanoparticles imaging agents in theranostic and biomedical imaging is receiving considerable attention in recent years, the research teams involving physicists and material chemists are interest in the multifunctional mesoporous silica nanoparticles (MSNs) because of the dual-model for imaging and therapy. This field is expanding rapidly, bringing a new term: theranostic, which is a combination of therapeutics and diagnostics. Comparing with the traditional imaging agent, the MSNs have many advanced features to develop into a multifunctional platform by elaborate design, in order to improve the sensitivity of cellular examination and the effect of targeting. In this study, we will synthesize the multifunctional MSNs combining dual imaging, cellular control and folate-modified, and containing the ability of therapy and diagnosis to apply to theranostic and biomedical imaging. This combinative multifunctional MSNs being imaging and therapeutic agent can accumulate a sufficient amount at lesion, with great prospects of theranostic for the future. This research conducts with three parts: first, we doped Eu3+ and Gd3+ into the MSNs to synthesize the EuGd-MSN with the fluorescence and magnesium dual imaging function; secondly, we will conjugate the intracellular-controlled drug on MSNs; finally, the folate molecular is going to graft on the EuGd-MSN/drug. According to our research experience, we can bring the dual imaging, cellular control and folate together by optimal conditions to prepare the multifunctional EuGd-MSN/drug/folate. We will respectively investigate the physical and chemical properties of EuGd-MSN/drug/folate, and test the in vitro and in vitro assessment."

Keyword(s)

葉酸標定
癌症治療
藥物控制釋放
智慧型藥物遞送系統
細胞內控制藥物遞送系統
雙重顯影
標靶治療
診斷治療奈米粒子
in vitro
in vivo
Folate-targeting
Cancer Therapy
Drug Controlled Release
Intelligent Drug Delivery
Intracellular-controled Drug Delivery System
Dual Imaging
Targeting Therapy
Theranostic Nanoparticles

DSpace CRIS

Preparation Multifunctional Mesoporous Silica Nanoparticle

基本資料

Description