Assessing the Ingestion Exposure and Health Risk for Citrus Pesticide Related Manufacturing, Using, and Agriculture Product Consuming Groups

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基本資料

Project title

Code/計畫編號

MOST109-2221-E019-033

Translated Name/計畫中文名

柑橘農藥生產製造與使用者之膳食暴露與健康風險評估

Project Coordinator/計畫主持人

Min-Pei Ling

Funding Organization/主管機關

National Science and Technology Council

Department/Unit

Department of Food Science

Website

https://www.grb.gov.tw/search/planDetail?id=13531648

Year

2020

Start date/計畫起

01-08-2020

Expected Completion/計畫迄

30-10-2021

Bugetid/研究經費

566千元

ResearchField/研究領域

公共衛生學

本計畫延續109年度計畫成果，並整合國立成功大學蔡朋枝教授「柑橘農藥生產製造與使用者之呼吸道暴露與健康危害風險評估」、中山醫學大學王櫻芳助理教授「柑橘農藥生產製造與使用者之皮膚暴露與健康危害風險評估」、及中國醫藥大學鍾季容副教授「柑橘農藥生產製造與使用者之生物偵測與流行病學研究調查」，深入研究臺灣農藥生產製造與使用者之職業暴露風險，除了考慮膳食暴露外，亦加入其他計畫所進行之吸入與皮膚接觸調查結果，以高種植率與高檢出率之柑橘類農作物為例，來評估柑橘類農藥生產製造與使用者之職業暴露風險。本計畫將評估一般消費者之膳食暴露風險，來對照109年度職業暴露風險之差異，同時將針對生物偵測結果修正暴露推估模式。本計畫分析馬拉松(Malathion)、丁基加保扶(Carbosulfan)、大滅松(Dimethoate)、嘉磷塞(Glyphosate)、及陶斯松(Chlorpyrifos)於食品中的殘留，並利用機率風險評估架構，以藥理動態學(Pharmacodynamics, PD)模式/耐受分佈(Tolerance Distribution)模式，結合不同生命階段(Life-Stage)之生理為基礎之藥理動力學(Physiologically-based Pharmacokinetics, PBPK)模式，建構柑橘農藥生產製造與使用者研究組與一般消費者對照組，在不同暴露途徑下，農藥殘留暴露劑量、年齡與反應的關係，並模擬人體體內各器官之吸收、分佈、代謝與排除，並考量年齡生理狀態之潛在變化，來描述不同暴露族群農藥殘留之暴露風險。故本研究為精準推估農藥累積於人體之劑量，將以生理為基礎之藥理動力學(PBPK)模式來推估農藥於人體各標的器官之累積劑量，並採用藥理動態學(PD)模式評估累積各標的器官劑量與各危害間之關係，再整合PBPK/PD與PBPK/ Tolerance Distribution模式所得之暴露與效應分析結果，最後建構人體的暴露劑量與致癌/非致癌之風險，以更精確量化不同暴露族群因受農藥暴露之健康風險，並能比較不同暴露族群之風險差異。最後將根據造成人體潛在致癌/非致癌風險為基礎，建議職業暴露與飲食中農藥殘留限值，提供風險管理(Risk Management)的依據。 This study is to assess the occupational exposure risk from malathion, carbosulfan, dimethoate, glyphosate, and chlorpyrifos concentrations through oral, inhalation, and dermal exposure for citrus pesticide related manufacturing, using, and agriculture product consuming groups. The purpose of this study is to develop a biologically-based probabilistic risk assessment integrated framework for age-specific human health risks through oral, inhalation, and dermal exposure for citrus pesticide related manufacturing, using, and agriculture product consuming groups. Furthermore, we also to estimate the probabilistic risk assessment through oral exposure for general consumer. We present an integrated approach by linking the pharmacodynamic (PD) model/ Tolerance distribution model and a physiologically based pharmacokinetic (PBPK) model to construct the interplay among pesticide residue exposure dose, age and response for citrus pesticide related manufacturing, using, agriculture product consuming groups, and general consumer. A life-stage PBPK model is used to describe the absorption, distribution, metabolism and excretion of the different pesticides in human target tissue groups, considering the potential impact by physiologically life-stage differences. Furthermore, the purpose of this study is to evaluate a reasonable occupational exposure risk management based on the probabilistic risk assessment, and also to determines the pesticide residue limit for agricultural products based on the estimates of potential carcinogenic risks in Taiwan.

Keyword(s)

農藥殘留
生理為基礎之藥理動力學模式
藥理動態學模式
機率風險評估
風險管理
Pesticide Residue
Physiologically-based Pharmacokinetic (PBPK) Model
Pharmacodynamic (PD) model
Probabilistic Risk Assessment
Risk Management

DSpace CRIS

Assessing the Ingestion Exposure and Health Risk for Citrus Pesticide Related Manufacturing, Using, and Agriculture Product Consuming Groups

基本資料

Description