Effect of Dietary Chitosan and Chitooligosaccharide on Lipid Metabolism and Colonial Physiology (III)

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Project title

Code/計畫編號

NSC89-2313-B019-068-A24

Translated Name/計畫中文名

膳食幾丁聚醣及幾丁寡糖對脂質代謝及腸導生理的影響(III)

Project Coordinator/計畫主持人

Meng-Tsan Chiang

Funding Organization/主管機關

National Science and Technology Council

Department/Unit

Department of Food Science

Website

https://www.grb.gov.tw/search/planDetail?id=553315

Year

2000

Start date/計畫起

01-08-2000

Expected Completion/計畫迄

01-07-2001

Bugetid/研究經費

606千元

ResearchField/研究領域

食品科技(農)

本研究為了解幾丁聚醣對於糖尿病病人血脂質、血糖之影響，以第二型糖尿病併發高脂血症病人為實驗對象，並將幾丁聚醣及菊醣添加在餅乾中，依餅乾中所含之纖維質不同分成三組，分別為(1) Placebo (2) Chitosan (3) Chitosan + Inulin，每天攝食含幾丁聚醣(每片含1g幾丁聚醣)或幾丁聚醣加菊醣餅乾二次(每片含1g幾丁聚醣，0.2g菊醣)，實驗採Double blind的方式，一共進行12週。實驗結果發現，攝食幾丁聚醣餅乾的病人並不含會影響血漿中血糖的濃度，但Chitosan + Inulin組的血漿HbA1c有下降的趨勢。在血脂質濃度方面，無論攝食幾丁聚醣或幾丁聚醣加菊醣餅乾，病人血漿三酸甘油脂有上升的趨勢，但是血漿總膽固醇則有下降的趨勢。值得注意的是，Placebo組之血漿總膽固醇濃度卻會明顯下降。雖然幾丁聚醣組有低的血漿LDL-膽固醇濃度，而菊醣的添加則會使此作用更加明顯(P<0.05)。另外在病人的體重、基礎代謝率、腰臀比、體脂肪、收縮壓變化上皆無明顯變化。由以上結果顯示，攝食幾丁聚醣餅乾有助於降低糖尿病病人血漿中LDL-膽固醇濃度。 The metabolism of glucose and lipid has been studied in diabetic subjects with hypercholesterolemia received chitosan biscuit for 12 weeks. All the subjects were divided into 3 groups by double blind way. The 3 groups are (1) Placebo group (2) Chitosan group (3) Chitosan + lnulin group. Although no significant difference in body weight, blood pressure, plasma total cholesterol and HDL cholesterol was observed in subjects after chitosan or chitosan + inulin treatment, a significant decrease in LDL cholesterol was found in chitosan + inulin group. Low plasma HbA1c level was observed in subjects after chitosan or chitosan + inulin treatment, but there is no significant difference. Results from this study showed that inulin supplementation may play an important role in decrease in plasma LDL cholesterol in Type 2 diabetic subjects after chitosan treatment.

Keyword(s)

幾丁聚醣
脂質代謝
腸道生理
膽固醇
幾丁寡醣
膳食
Chitosan
Lipid metabolism
Intestinal physiology
Cholesterol
Chitooligosaccharide
Diet

DSpace CRIS

Effect of Dietary Chitosan and Chitooligosaccharide on Lipid Metabolism and Colonial Physiology (III)

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