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  1. National Taiwan Ocean University Research Hub

Using the Influenza Virus a Infection Mouse Model to Investigate the Antiviral Effects and Synergistic Mechanism of Ulva Lactuca Water Extracts and Lactobacillus Plantarum

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Project title
Using the Influenza Virus a Infection Mouse Model to Investigate the Antiviral Effects and Synergistic Mechanism of Ulva Lactuca Water Extracts and Lactobacillus Plantarum
Code/計畫編號
NSTC113-2221-E019-006-MY3
Translated Name/計畫中文名
利用A型流感病毒感染小鼠模式探討胚芽乳酸桿菌(Lactobacillus plantarum)與石蓴多醣之抗病毒效果及其協同機制
 
Project Coordinator/計畫主持人
Chang-Jer Wu
Funding Organization/主管機關
National Science and Technology Council
 
Department/Unit
Department of Food Science
Website
https://www.grb.gov.tw/search/planDetail?id=16556374
Year
2024
 
Start date/計畫起
01-08-2024
Expected Completion/計畫迄
31-07-2025
 
Bugetid/研究經費
1500千元
 
ResearchField/研究領域
食品科技(工)
 

Description

Abstract
近年來,克流感已出現抗藥性及副作用,解封後的「免疫負債」導致流感病例激增,因此開發有效預防流感病毒感染的藥物是迫切議題。本計畫在探討口服或鼻腔的方式給予石蓴多醣(益生元)與胚芽乳酸桿菌(益生菌)對於A型流感病毒感染是否具保護效果,及其是否藉由改善腸道菌相的平衡來調節免疫系統,達到降低小鼠肺部發炎所造成的肺損傷情形,以作為抗A型流感保健食品及藥物開發之應用。故計劃具有必要性、學術價值及產業發展性
 
Keyword(s)
A型流感病毒
抗病毒
胚芽乳酸桿菌
益生菌
石蓴多醣
益生元
腸道菌相
肺部損傷
免疫調節
Influenza A virus
Antiviral
Lactobacillus plantarum
Probiotics
Ulvan
Prebiotics
Microbiota
Lung injury
Immunomodulation
 
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