http://scholars.ntou.edu.tw/handle/123456789/10 2026-04-24T14:45:05Z 2026-04-24T14:45:05Z Chen, Zheng-Zhe Lin, Hsiang-Ting Chang, Chiao-Yun Adil, Muhammad Tsai, Po-Cheng Kao, Tsung Sheng Chen, Chi Lin, Shih-Yen Shih, Min-Hsiung http://scholars.ntou.edu.tw/handle/123456789/26455 2026-03-12T03:36:45Z 2025-01-01T00:00:00Z

標題: Electrically-Driven 2D Semiconductor Microcavity Laser 作者: Chen, Zheng-Zhe; Lin, Hsiang-Ting; Chang, Chiao-Yun; Adil, Muhammad; Tsai, Po-Cheng; Kao, Tsung Sheng; Chen, Chi; Lin, Shih-Yen; Shih, Min-Hsiung 摘要: 2D monolayered transition-metal dichalcogenides (TMDCs) are promising materials for realizing ultracompact, low-threshold semiconductor lasers. And the development of the electrical-driven TMDC devices is crucial for enhancing the integration potential of practical optoelectronic systems. However, at the current stage, the electrically-driven 2-D TMDC laser has never been realized. Herein, the first electrically-driven 2-D TMDC microcavity laser have been developed. In this device, an alternating current (AC) generates electroluminescence lasing in suspended monolayered WSe2 integrated on a microdisk cavity. The input-output curve, bandwidth narrowing, and second-order coherence is analyzed to confirm the lasing characteristics at room temperature. The realization of the room-temperature AC-driven 2-D TMDC laser establishes a new area of research on electrically pumped compact lasers and is likely to assist with the implementation of diverse TMDC-based practical photonic devices in the future.

2025-01-01T00:00:00Z Shiu, Ruei-Feng Chen, Tzu-Jung Nan, Fan-Hua Tsao, Hsiao-Chang Ling, Min-Pei http://scholars.ntou.edu.tw/handle/123456789/26366 2026-03-12T03:36:18Z 2025-01-01T00:00:00Z

標題: Risk-based integrated framework for evaluating effects of microplastics to aquatic ecosystems and human health 作者: Shiu, Ruei-Feng; Chen, Tzu-Jung; Nan, Fan-Hua; Tsao, Hsiao-Chang; Ling, Min-Pei 摘要: The widespread presence of microplastics (MPs) in environments and the food web is a serious concern for both aquatic ecosystems and human health. Most studies have used single tool to assess risks primarily to organisms and humans, leaving gaps in comprehensive risk assessments. This study conducted an investigation of MP abundances in surface water and wild oysters from natural estuaries of major rivers in Taiwan. Additionally, the data also used to develop an integrated risk-based framework for evaluating potential risks from organisms to human MP exposure to seafood consumption. We assessed aquatic ecological risk quotients (RQ), oyster mortality exceedance risk (ER), human MP intake exposure, and human liver damage ER. Our data showed that MP abundances ranged from 0.025 to 4.701 items/m3 and 0.015-2.374 items/g (wet weight) in water and oysters, respectively. Although RQ values indicate negligible risk for aquatic ecosystems, but oyster mortality ER results from oysters exposed to MPs showed a 6 % increase in mortality (10 % risk). The probabilistic representation of risk curves of MPs for alanine aminotransferase (ALT) levels in human serum was found to be low, indicating minimal health risk to humans. Overall, our data suggest that relying on a single risk indicator may underestimate potential risks, multi-faceted tools are recommended for assessing organism and human health.

2025-01-01T00:00:00Z Hsu, Wen-yi http://scholars.ntou.edu.tw/handle/123456789/26358 2026-03-12T03:36:15Z 2025-01-01T00:00:00Z

標題: Qualitative analysis of structural holes in emerging media industries: Evidence from Taiwan's Over-The-Top Industry 作者: Hsu, Wen-yi 摘要: This study examined the relationships, structural holes, and structural hole spanners among Taiwan's over-the-top (OTT) operators. It explored whether Taiwan's local OTT operators can serve as bridges or structural hole spanners within this network. Qualitative structural analysis was performed, in-depth interviews were conducted, and data were analyzed using a grounded theory approach. Five themes were identified: (1) loose networks among local Taiwanese OTT players, with Netflix as a bridge; (2) Netflix as a structural hole spanner in Taiwan's OTT network; (3) Netflix's advantage from being a structural hole spanner, with local players lacking a reciprocal relationship; (4) reinforced structural holes in the Taiwanese OTT industry; and (5) opportunities for local Taiwanese OTT operators to gain an advantage. The findings identified the existence of structural holes and the following four dimensions of disconnection: structural holes from a lack of global-scale capital among local players, structural holes due to an imbalance between production and sales, weakness of local platforms leading to expanded structural holes, and structural holes in the OTT industry allowing piracy actors to play bridging roles. Domestic operators lack strong platforms, market share, and scale, with most struggling to build brands, highlighting their limited key resources. Overall, domestic operators hold no significant competitive advantage. The findings pave the way for identifying strategies to improve the industry's structure to prevent local OTT players from becoming even more marginalized.

2025-01-01T00:00:00Z Lin, Chi Chao, Hsin-Yi Cheng, Tsai-Mu Shih, Chun-Ming Wu, Alexander T. H. Cheng, Chia-Hsiung Hsiao, Chen Yuan Lu, Hsin-Ying Shih, Chun-Che Mi, Fwu-Long http://scholars.ntou.edu.tw/handle/123456789/26263 2026-03-12T03:20:44Z 2026-01-01T00:00:00Z

標題: Pathology-tailored nanotherapy via Galectin-3-targeted and triple-responsive nanoparticles enables multimodal therapy against aortic dissection 作者: Lin, Chi; Chao, Hsin-Yi; Cheng, Tsai-Mu; Shih, Chun-Ming; Wu, Alexander T. H.; Cheng, Chia-Hsiung; Hsiao, Chen Yuan; Lu, Hsin-Ying; Shih, Chun-Che; Mi, Fwu-Long 摘要: Aortic dissection (AD) is a life-threatening vascular disorder with high mortality and no effective pharmacological treatment. Addressing its multicellular and dynamic pathology requires strategies that precisely modulate inflammatory and degenerative processes, yet existing targeted delivery approaches lack the spatiotemporal and cellular precision required. Here, we establish Galectin-3 (Gal-3) as a therapeutic delivery target for cardiovascular nanomedicine and introduce a modular, pathology-tailored nanoplatform synergizing nitric oxide (NO) therapy with multi-pathway intervention. Gal-3 is persistently expressed on inflamed endothelial cells, macrophages, and smooth muscle cells during AD progression, providing a tractable target for lesion-specific engagement. The nanoparticles, created from a previously unexplored integration of a Gal-3-binding polysaccharide, a nitric oxide-generating peptide, and a hydrophobic drug carrier, uniquely combine triple responsiveness to pH, protease, and oxidative stress with on-demand NO release and controlled resveratrol co-delivery. In vitro, they enhanced uptake across pathological cell types and attenuated inflammatory and degenerative phenotypes. In vivo, they achieved early lesion targeting, > 20-fold aortic accumulation, and marked reductions in AD incidence, vascular degeneration, and mortality. This work establishes Gal-3-targeted nanotherapy as a broadly applicable paradigm for pathology-adaptive intervention in AD and one that may be adapted for broader cardiovascular applications.

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