DSpace 集合:http://scholars.ntou.edu.tw/handle/123456789/2062024-03-28T08:40:24Z2024-03-28T08:40:24ZNIR-activated quercetin-based nanogels embedded with CuS nanoclusters for the treatment of drug-resistant biofilms and accelerated chronic wound healingNain, AmitTseng, Yu-TingGupta, AkashLin, Yu-FengArumugam, SangiliHuang, Yu-FenHuang, Chih-ChingChang, Huan-Tsunghttp://scholars.ntou.edu.tw/handle/123456789/247012024-03-06T03:51:31Z2023-01-01T00:00:00Z標題: NIR-activated quercetin-based nanogels embedded with CuS nanoclusters for the treatment of drug-resistant biofilms and accelerated chronic wound healing
作者: Nain, Amit; Tseng, Yu-Ting; Gupta, Akash; Lin, Yu-Feng; Arumugam, Sangili; Huang, Yu-Fen; Huang, Chih-Ching; Chang, Huan-Tsung2023-01-01T00:00:00ZAugmenting Neutrophil Extracellular Traps with Carbonized Polymer Dots: A Potential Treatment for Bacterial SepsisLin, Chin-JungHwang, Tsong-LongWang, Robert Y. L.Nain, AmitShih, Ren-HongChang, LungLin, Han-JiaHarroun, Scott G.Chang, Huan-TsungHuang, Chih-Chinghttp://scholars.ntou.edu.tw/handle/123456789/246592024-03-05T08:05:45Z2024-01-01T00:00:00Z標題: Augmenting Neutrophil Extracellular Traps with Carbonized Polymer Dots: A Potential Treatment for Bacterial Sepsis
作者: Lin, Chin-Jung; Hwang, Tsong-Long; Wang, Robert Y. L.; Nain, Amit; Shih, Ren-Hong; Chang, Lung; Lin, Han-Jia; Harroun, Scott G.; Chang, Huan-Tsung; Huang, Chih-Ching2024-01-01T00:00:00ZFunctionalization of rice husk-derived mesoporous silica nanoparticles for targeted and imaging in cancer drug deliveryChen, Shiow-YiJian, Jhih-YunLin, Hsiu-Meihttp://scholars.ntou.edu.tw/handle/123456789/246392024-03-05T07:59:17Z2024-01-01T00:00:00Z標題: Functionalization of rice husk-derived mesoporous silica nanoparticles for targeted and imaging in cancer drug delivery
作者: Chen, Shiow-Yi; Jian, Jhih-Yun; Lin, Hsiu-Mei
摘要: BACKGROUNDRice, a pivotal global food staple, annually accumulates vast amounts of rice husks, resulting in substantial environmental impact. Exploiting the high silica content in rice husk, our research aimed to recycle this agricultural byproduct to synthesize mesoporous silica nanoparticles (rMSNs). These nanoparticles were further modified to evaluate their potential as effective carriers for cancer drug delivery.RESULTSrMSNs showed high biocompatibility, large surface area and porous structure as MSNs, making them excellent drug carriers. Further modifications were applied to rMSNs, such as the incorporation of the lanthanides europium and gadolinium into rMSNs, making them fluorescent and magnetic for detection and tracking using confocal fluorescence microscopy and magnetic resonance imaging. Additionally, folic acid and aptamer AS1411 were conjugated with rMSNs to enhance the targeting of cancer cells. HeLa cells exhibited higher uptake of camptothecin (CPT)-loaded rMSNs compared to normal fibroblast cells (L929). The linkage of disulfide bonds to rMSNs also allowed CPT to be carried by rMSNs and released intracellularly in the presence of the abundant reducing agent glutathione. The validation of rMSNs in vitro and in vivo proved their practical feasibility.CONCLUSIONOur findings indicate that low-cost rMSNs, derived from recycled agricultural waste, can replace highly valuable MSNs. Functionalized rMSNs exhibit promising capabilities in transporting clinical drugs to specific aberrant tissues and offering dual-targeting and dual-imaging functionalities for enhanced cancer therapy. (c) 2023 Society of Chemical Industry.2024-01-01T00:00:00ZWnt3a Facilitates SARS-CoV-2 Pseudovirus Entry into CellsMelano, IvonneChen, Hui-JyeNgwira, LovenessHsu, Pang-HungKuo, Li-LanNoriega, LloydSu, Wen-Chihttp://scholars.ntou.edu.tw/handle/123456789/246382024-03-05T07:53:28Z2024-01-01T00:00:00Z標題: Wnt3a Facilitates SARS-CoV-2 Pseudovirus Entry into Cells
作者: Melano, Ivonne; Chen, Hui-Jye; Ngwira, Loveness; Hsu, Pang-Hung; Kuo, Li-Lan; Noriega, Lloyd; Su, Wen-Chi
摘要: How ACE2 functions as the major host receptor of SARS-CoV-2 despite having low expression in the lungs is still unknown. To facilitate the development of therapeutic strategies against coronaviruses, gaining a deeper comprehension of the molecular mechanism of SARS-CoV-2 infection is imperative. In our previous study, we identified several potential host factors of SARS-CoV-2 using an shRNA arrayed screen, one of which was Wnt3a. Here, we validated the significance of Wnt3a, a potent activator of the Wnt/beta-catenin signaling pathway, for SARS-CoV-2 entry into cells by evaluating the effects of its knockdown and overexpression on SARS-CoV-2 pseudotyped virus entry. Further analysis revealed that SARS-CoV-2 pseudotyped virus infection activates the canonical Wnt/beta-catenin signaling pathway, which we found could subsequently stimulate ACE2 transcription. Collectively, our study identified Wnt3a as an important host factor that facilitates ACE2-mediated virus infection. Insight into the virus entry mechanism is impactful as it will aid in developing novel therapeutic strategies against current and future coronavirus pandemics.2024-01-01T00:00:00Z