http://scholars.ntou.edu.tw/handle/123456789/193 Tue, 11 Aug 2026 04:48:49 GMT 2026-08-11T04:48:49Z https://scholars.ntou.edu.tw:443/retrieve/75/海洋政策碩士學位學程(研究所).jpg http://scholars.ntou.edu.tw/handle/123456789/193 http://scholars.ntou.edu.tw/handle/123456789/26763 標題: Adiponectin improves clozapine-induced lipid accumulation and inflammation without affecting insulin resistance 作者: Tsai, I-Lun; Lin, Shih-Chao; Lin, Lin; Tsai, Pei-Shan; Chen, Shiow-Yi 摘要: Clozapine, an atypical antipsychotic, is effective for treatment-resistant schizophrenia but frequently causes metabolic adverse effects, including hepatic lipid accumu-lation, inflammation and insulin resistance. Adiponectin, an adipocyte-derived cytokine with anti-inflammatory and insulin-sensitizing properties, may counteract these effects; however, its ability to mitigate clozapine-induced hepatic alterations remains unclear. This study examined whether adiponectin overexpression reduces clozapine-induced lipid accumulation, inflammatory signaling, and whether it restores insulin-related Akt signaling in human HepG2 liver cells. Cells were treated with 25 mu M clozapine for 24 or 48 h, and adiponectin was overexpressed by plasmid transfection. Lipid accumulation was quantified by BODIPY staining. AdipoR1 and AdipoR2 expression was analyzed by qPCR, and protein levels of FASN, phosphorylated NF-kappa B, and phosphorylated Akt were assessed by Western blotting. Clozapine increased lipid accumulation, upregulated FASN, and reduced AdipoR1 and AdipoR2 expression. Adiponectin overexpression significantly decreased lipid levels, which was associated with reduced NF-kappa B phosphorylation, suggesting attenuation of inflammatory signaling. However, adiponectin did not restore insulin-stimulated Akt phosphorylation. In summary, adiponectin selectively reduced clozapine-induced lipid accumulation and inflammatory signaling in HepG2 cells, whereas impaired insulin-stimulated Akt phosphorylation remained unchanged under the present experimental conditions. These findings indicate a selective protective role of adiponectin and suggest its potential as a modulator of clozapine-induced metabolic side effects. Thu, 01 Jan 2026 00:00:00 GMT http://scholars.ntou.edu.tw/handle/123456789/26763 2026-01-01T00:00:00Z http://scholars.ntou.edu.tw/handle/123456789/25627 標題: Monophosphate Derivatives of Luteolin and Apigenin as Efficient Precursors with Improved Oral Bioavailability in Rats 作者: Wu, Sydney; Wang, Shang-Ta; Chen, Guan-Yuan; Hsu, Chen; Chen, Yi-Hsin; Tsai, Hsin-Ya; Weng, Te-, I; Chen, Chien-Li; Wu, Yi-Fang; Su, Nan-Wei 摘要: Luteolin (Lut) and apigenin (Apn), flavones present in various edible plants, exhibit diverse antioxidant and pharmacological activities but have limited in vivo efficacy due to low water solubility and poor bioavailability. Here, we generated luteolin and apigenin monophosphate derivatives (LutPs and ApnPs) individually via microbial biotransformation. We then characterized their physicochemical properties and evaluated their in vitro and in vivo pharmacokinetics and bioavailability. Both LutPs and ApnPs showed enhanced solubility and dissolution and remained stable in simulated gastrointestinal conditions. Additionally, they efficiently reverted to parental forms via alkaline phosphatase in Caco-2 cells. Following oral administration in rats, LutPs and ApnPs exhibited higher plasma exposure to both aglycone and conjugated forms compared to Lut and Apn. Notably, the in vivo biotransformation of Apn to Lut was observed in all apigenin-related groups. Our study suggests that flavone monophosphates are effective alternatives with enhanced bioavailability, providing insights for the potential application of emerging bioactive nutraceuticals. Mon, 01 Jan 2024 00:00:00 GMT http://scholars.ntou.edu.tw/handle/123456789/25627 2024-01-01T00:00:00Z http://scholars.ntou.edu.tw/handle/123456789/23247 標題: The Diminishing Public Domain with Regard to the Copyright in the Digital Age 作者: 江雅綺 摘要: This work begins with a crude observation of copyright developments and focuses on discussing the recent expansion movement of copyright regime in response to the digital age. Then in the next chapter, I will begin to discuss the meaning and the importance of the public domain in the copyright regime. While arguing a positive definition of the public domain is needed, the attempt to recognize and emphasize its importance is also urgent. My conclusion is that, the diminishing public domain in the name of fighting the digital technology is not justified, particularly when considering the very purpose of the existence of the copyright regime is to ensure that a good balance is struck between the public and private interests. Finally, following the opinions formed in the previous chapters, if the expansion of copyright is not a panacea to cure the digital syndrome, what should we do when facing the ferocious digital revolution? I will give a brief introduction on the current technological and legal solutions, and conclude that there is no conflict between the usage of the law and technology. 描述: https://www.nhu.edu.tw/~society/jccic/09/ab/9-07.pdf Fri, 01 Jul 2005 00:00:00 GMT http://scholars.ntou.edu.tw/handle/123456789/23247 2005-07-01T00:00:00Z http://scholars.ntou.edu.tw/handle/123456789/23246 標題: 臺灣的聯合國會員資格 作者: 江雅綺 描述: Paust, Jordan J.著，江雅綺譯 Sat, 01 Sep 2007 00:00:00 GMT http://scholars.ntou.edu.tw/handle/123456789/23246 2007-09-01T00:00:00Z