http://scholars.ntou.edu.tw/handle/123456789/208 Mon, 24 Aug 2026 18:25:47 GMT 2026-08-24T18:25:47Z https://scholars.ntou.edu.tw:443/retrieve/90/食品科學系.jpg http://scholars.ntou.edu.tw/handle/123456789/208 http://scholars.ntou.edu.tw/handle/123456789/26803 標題: Plasma-engineered chitosan couples red-light bioenergetics to diabetic wound regeneration through programmable microenvironments 作者: Rethi, Lekshmi; Chau, Hoa Duc; Febriani, Erlina; Chen, Yan-Ting; Tung, Szu-Yu; Jheng, Pei-Ru; Tseng, Yu-Wen; Li, Rou; Tsai, Min-Lang; Chang, Chun-Chi; Pham, Van Khiet; Nguyen, Hieu Trung; Chuang, Andrew E. -Y. 摘要: Diabetic wounds remain trapped in a non-healing loop driven by oxidative stress, impaired bioenergetics, and persistent inflammation. Here, we report a cold atmospheric plasma (CAP)-engineered chitosan-microalgae (CS-CHL) photobioactive dressing that converts a carbohydrate matrix into a programmable photosynthetic interface for wearable 660-nm activation. CAP remodeled the CS microenvironment in a duration-dependent manner, as verified by FTIR/XRD/NMR, and yielded a distinct optimum at 30 s with the most favorable polymer reorganization and coupling to CHL. This just-right" window tuned photochemical branching under red light showing the strongest oxygen-sensitive response as reflected by the lowest O-2 quenching index (similar to 66.3% indicating the greatest probe quenching and thus higher O-2 availability) while simultaneously enhancing reductive bioenergetic outputs including hydrogen production (similar to 117.6%) and MPP-Production (similar to 116.4%) accompanied by the strongest light-responsive electrochemical signal. In an STZ-induced diabetic full-thickness wound model CS-CHL + 660 nm accelerated macroscopic wound closure versus wound-only and CS controls while systemic hematological indices remained comparable across groups. Mechanistic tissue profiling further supported coordinated inflammation suppression angiogenic/regenerative recovery ROS reduction mitochondrial functional restoration and activation of mitophagy/autophagy-associated pathways. Collectively CAP-tuned carbohydrate microenvironments provide a powerful route to program microalgal photobioenergetics and enable light-assisted diabetic wound repair." Thu, 01 Jan 2026 00:00:00 GMT http://scholars.ntou.edu.tw/handle/123456789/26803 2026-01-01T00:00:00Z http://scholars.ntou.edu.tw/handle/123456789/26806 標題: Carnosic Acid Attenuates TNF-α-Induced Insulin Resistance by Regulating Mitochondrial Function in 3T3-L1 Adipocytes 作者: Lin, Chia-Yuan; Chan, Lok-, I; Chang, Yu-Hsuan; Lu, Meng-Chun; Tsai, Chia-Wen 摘要: The disruption of mitochondrial homeostasis is a trigger for insulin resistance. The loss of N-acetyltransferase 1 (Nat1) function, an insulin-sensitivity gene, contributes to mitochondrial dysfunction and insulin resistance. Carnosic acid (CA), a diterpene derived from rosemary, has demonstrated an anti-insulin-resistance effect. This study hypothesized that CA protects against TNF-alpha-induced insulin resistance in 3T3-L1 adipocytes by regulating mitochondrial dynamics, biogenesis, and function via Nat1. 3T3-L1 adipocytes were pretreated with CA for 12 h, followed by co-treatment with TNF-alpha for an additional indicated duration. Results showed that treatment of 3T3-L1 adipocytes with TNF-alpha decreases mitochondrial membrane potential (MMP) and PGC-1 alpha protein levels and alters mitochondrial fission/fusion dynamics. Pretreatment with CA improved these effects. In parallel, CA prevented the TNF-alpha-induced reduction in Nat1 protein and improved insulin signaling by suppressing the phosphorylation of insulin receptor substrate-1 (IRS-1) at serine(307), while restoring the phosphorylation of IRS-1 at tyrosine(628) and Akt. Moreover, transfection with Nat1 siRNA inhibited the protective effect of CA against TNF-alpha-induced reductions in MMP, PGC-1 alpha, and insulin signaling. In conclusion, CA ameliorated TNF-alpha-induced insulin resistance by reducing mitochondrial dysregulation by Nat1. Thu, 01 Jan 2026 00:00:00 GMT http://scholars.ntou.edu.tw/handle/123456789/26806 2026-01-01T00:00:00Z http://scholars.ntou.edu.tw/handle/123456789/26801 標題: Recent advances in the formulation and delivery applications of chitosan/ fucoidan nanoparticles 作者: Don, Trong-Ming; Pagilagan, Kathleen L.; Cruz, Kathlia D.; Tsai, Po-Wei; Huang, Yi-Cheng 摘要: In the last few years, marine polysaccharides have gained attention for their biological activities that are beneficial for several biomedical applications. Among them, chitosan and fucoidan are known for their biocompatibility, bioactivities, and biodegradability, making them desirable for drug delivery. Under suitable environmental conditions, chitosan can carry cationic charges and has a strong electrostatic interaction with the anionic fucoidan, leading to ionic crosslinking and resulting in a polyelectrolyte complex. Therefore, when used in combination as nanoparticles, various enhanced bioactivities such as antioxidant, anti-inflammatory, and antibacterial effects in drug delivery, regenerative medicine, and cancer treatment have been reported with little toxicity. With further chemical and physical modifications, it can encompass several additional properties suitable for its applications. Particularly, chitosan/fucoidan nanoparticles have been used for creating a drug or bioactive compound delivery system that results in improved drug solubility, stability, and bioavailability. This review aims to present the recent advancements and applications of chitosan/fucoidan formulations and nanoparticles and their benefits in biomedical applications, particularly in drug delivery applications. Thu, 01 Jan 2026 00:00:00 GMT http://scholars.ntou.edu.tw/handle/123456789/26801 2026-01-01T00:00:00Z http://scholars.ntou.edu.tw/handle/123456789/26794 標題: Consumer Use of Package-Level Food Safety Information in Imported Packaged Foods: Perceived Hazards, Label Trust, and Market Entry in Taiwan 作者: Chen, Yan-An; Fang, Ming-Chih; Chen, Yen-Hua; Chuang, Pei-Ting 摘要: Imported packaged foods are often purchased under conditions of limited consumer verification, where consumers cannot directly confirm safety-related attributes at the point of purchase and must rely on package-level label information as a visible cue of product identity, disclosure, and apparent safety. This study examined how food safety risk perception, trust in packaging-label information, and food neophilia were associated with consumer engagement with imported packaged foods in Taiwan. An self-administered online survey was completed by 454 adults in Taiwan. The questionnaire assessed perceived food safety hazards, trust in packaging-label information, food neophilia, and imported packaged food purchasing. Descriptive statistics, reliability analysis, bivariate correlations, Friedman tests, a market-entry logistic model, a purchaser-only ordered logistic model, and item-level Mann-Whitney U tests were applied. The highest-rated perceived hazards were unknown ingredients whose safety could not be confirmed, illegal food additives, pesticide residues, natural food toxins, and microbiological contamination. The most trusted package-level label information items were expiry date, ingredient declaration, and disclosure of food additive names. Food safety risk perception was associated with lower odds of market entry, whereas trust in packaging-label information was associated with higher odds of ever having purchased imported packaged foods. Among prior purchasers, food neophilia was associated with higher odds of being in a more frequent purchase category. Item-level comparisons further showed that never-purchasers reported greater concern about all retained food safety risk items, with the largest difference observed for microbiological contamination. These findings suggest that package-level label information functions as a consumer-facing food safety cue, but it should be interpreted as a partial cue rather than as direct evidence of product safety. Thu, 01 Jan 2026 00:00:00 GMT http://scholars.ntou.edu.tw/handle/123456789/26794 2026-01-01T00:00:00Z