http://scholars.ntou.edu.tw/handle/123456789/20412
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Chi, Hsin | en_US |
dc.contributor.author | Hsiao, Kuang-Liang | en_US |
dc.contributor.author | Weng, Li-Chuan | en_US |
dc.contributor.author | Liu, Chang-Pan | en_US |
dc.contributor.author | Liu, Hsin-Fu | en_US |
dc.date.accessioned | 2022-02-17T03:53:30Z | - |
dc.date.available | 2022-02-17T03:53:30Z | - |
dc.date.issued | 2019-03-18 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | http://scholars.ntou.edu.tw/handle/123456789/20412 | - |
dc.description.abstract | The study aimed to characterize the molecular epidemiology, phylogenetic relationship, and population dynamics of the G protein gene in clinical respiratory syncytial virus (RSV) strains isolated from northern Taiwan. We analyzed a total of 160 and 116 G protein gene sequences of RSV-A and RSV-B representative strains, respectively, from 804 clinical viral stocks collected between July 2000 and June 2016. Population dynamic patterns of the RSV G protein gene were analyzed using Bayesian inference through the Markov chain Monte Carlo framework. A phylogenetic analysis revealed that RSV-A from Taiwan could be categorized into GA2, GA5, and GA7 lineages. GA2 of RSV-A could be further divided into NA1, NA2, NA4, and ON1 clades. These RSV-A lineages has been replaced over time, whereas RSV-B strains from Taiwan continually evolved from a single lineage with significant time-dependent waves. Four putative positive selection sites were observed in both RSV-A and RSV-B. The Bayesian skyline plot revealed that the local population dynamics of RSV were associated with lineage displacement events. Both circulating subtypes and population dynamics represented a unique local pattern. Our results affirm the necessity of continuing molecular surveillance of RSV to attain a more comprehensive understanding of epidemics. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | NATURE RESEARCH | en_US |
dc.relation.ispartof | SCI REP-UK | en_US |
dc.subject | ATTACHMENT G GLYCOPROTEIN | en_US |
dc.subject | MOLECULAR EVOLUTION | en_US |
dc.subject | SUBGROUP-B | en_US |
dc.subject | GENOTYPE | en_US |
dc.subject | DUPLICATION | en_US |
dc.subject | CIRCULATION | en_US |
dc.subject | SELECTION | en_US |
dc.subject | GENE | en_US |
dc.title | Persistence and continuous evolution of the human respiratory syncytial virus in northern Taiwan for two decades | en_US |
dc.type | journal article | en_US |
dc.identifier.doi | 10.1038/s41598-019-41332-9 | - |
dc.identifier.isi | WOS:000461416900002 | - |
dc.relation.journalvolume | 9 | en_US |
item.cerifentitytype | Publications | - |
item.grantfulltext | none | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.fulltext | no fulltext | - |
item.languageiso639-1 | en_US | - |
顯示於: | 03 GOOD HEALTH AND WELL-BEING |
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