Doppler Blood Flow Meter Development and Superficial Artery Vibration Measurement by Espi &Amp; Projection Morie

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基本資料

Project title

Code/計畫編號

MOST105-2221-E019-044

Translated Name/計畫中文名

以電子斑點干涉術與投影式疊紋量測超淺層動脈震動及都卜勒血液流速儀之研發

Project Coordinator/計畫主持人

Shu-Sheng Lee

Funding Organization/主管機關

National Science and Technology Council

Co-Investigator(s)/共同執行人

李世光

Department/Unit

Department of Systems Engineering and Naval Architecture

Website

https://www.grb.gov.tw/search/planDetail?id=11906826

Year

2016

Start date/計畫起

01-08-2016

Expected Completion/計畫迄

01-07-2017

Bugetid/研究經費

897千元

ResearchField/研究領域

自動化工程(工)

"本計畫以光學感測技術為基礎，開發超淺層動脈振動量測及血液流速儀，做為整合型計畫「具連續量測與自我校準功能的穿戴式血壓計」中負責光學檢測、校準和輔助設計的次系統計畫。整體計畫欲開發的標的血壓計，主要將採用壓電材料為主、次要將以光電感測技術為輔，且以穿戴式裝置為應用情境，因此無需增壓、非侵入式(non-invasive)、即時(real-time)血壓量測系統的光學感測技術，將是協助研發此類創新血壓計的重要檢測技術之一個分支。進一步的分析，傳統之侵入式血壓量測方式將壓力計置於血管中，雖可達到最精確的血壓量測值，但不適用於長時間的生活應用，而傳統非侵入式血壓計多需要應用血壓帶(cuff)來進行量測，因此面臨無法持續量測瞬時(continuous and instantaneous) 血壓值這個與穿載式裝置應用情境相牴觸的困境。所以本子項計畫，將以可搭配於穿戴式裝置(wearable device)的雷射都卜勒血液流速儀為第一個開發標的，以求能夠持續量測使用者的血液流速，搭配本團隊將在子計畫三所開發的血壓模型以及子計畫一所開發的壓電式壓力檢測元件(piezo-based pressure sensor)，來計算並且校正所量測到的人體血壓的即時數值。雷射都卜勒流速量測系統(Laser Doppler Flowmeter, LDF)主要藉由分析雷射光經紅血球散射後之光譜能量資訊來計算血壓。由於血壓分布情形不但因人而異，同時每個人在一天中的不同時段也會有所不同，因此本技術與壓電式壓力檢測元件利用脈衝傳遞時間(Pulse Transit Time, PTT)的方式，先共同進行一次血壓時間分布資料蒐集，即可以流速資料在血壓模型中可以依據不同的時間點校正計算出正確的血壓值，達成血壓量測之目的。超淺層動脈振動量測的技術研發，以可協助壓電式壓力感測元件的開發為首要目標、以可成為創新式血壓計的次系統為次要目標。研究過程中，將利用電子斑點干涉術(Electronic Speckle Pattern Interferometry, ESPI)與投影式疊紋(Projection moiré)的光學量測架構，來對於受測區域進行取像，並搭配自行開發的窗函式快速傅立葉轉換條紋解相技術，量測出血液脈衝於皮膚上超潛層振動，或者是量測分佈於皮膚上的壓力感測元件振動情形，並將這個量測資訊作為壓力感測元件的形狀設計基礎，融合其他子計畫成果，以求能夠整合成整個整合型計畫所將開發之連續量測與自我校準功能的穿戴式血壓計。" "The main goal of this proposal is first to pursue research and development of Doppler blood flow meter and related techniques for measuring the superficial artery vibration. This research direction is designed to serve as a sub-proposal of an integrated project entitled, “System development of cuffless wearable blood pressure monitor with continuous measurement and self-calibration capabilities” and with a mission to develop related optical metrology, calibration, and supporting sub-systems. The system will be integrated into a wearable device that the initial design is to use piezoelectric sensor as the primary sensing mechanism and optical technology as the supporting approach. The no constraint, non-invasive, and real time characteristics associated with the optical metrology will be invaluable for the development of the innovative blood pressure monitors to be developed by the Integrated project. In traditional invasive type blood pressure monitor, accurate blood pressure is obtained by inserting a manometer within the vein. However, health professional personnel must administrate this approach, which is thus not applicable for long-term daily usage. On the other hand, most of the traditional non-invasive blood pressure measurement demands the adoption of a cuff in order to provide continuous and instantaneous blood pressure. Nevertheless, long-term cuff usage is harmful to the health of the user and is not applicable for continuous blood pressure measurement. It is with this understanding that this sub-proposal plans to develop a minimized Doppler blood flow meter as the main target, which continuously measure the blood flow speed of the user. Integrating the above-mentioned result with the human body blood pressure model created by sub-proposal 3 and the array type piezo-based pressure sensor to be developed by sub-proposal 1 will lead to the ultimate goal of this integrated proposal, i.e., develop a wearable device that can provide instant and self-calibrated blood pressure accurately. Laser Doppler Flowmeter (LDF) system collect the scattering laser light spectrum from erythrocytes to calculate the blood pressure. Blood pressure is different from person to person and is different in different parts of a day even for the same person. The optical sensing technology mentioned above and planned for this sub-proposal and the pulse transient time (PTT) measured by array type piezoelectric sensor from sub-proposal 1 will be used simultaneously to measure the blood pressure versus time data. Fitting this flow speed information by using the human body blood pressure model from sub-proposal 3 lead to accurate calibrated blood pressure for different parts of a day. It is worth noting that this calibration only need to be implemented when the blood pressure monitor is to be personalized by the user for the first time. The primary goal of superficial artery vibration measurement is to support the development of the piezoelectric array. The secondary goal is to integrate this sensing technique directly into the final wearable blood pressure monitor. Electronic Speckle Pattern Interferometry (ESPI) and projection moiré will serve as the optical measurement framework for taking interference intensity images from the tested area. The newly developed windowed Fast Fourier Transform (FFT) techniques are to retrieve the phase from the interference intensity images, which lead to superficial artery vibration displacement on the skin induced by the blood pulse on the skin. This technique can be used to measure the vibration on the piezoelectric array as well, which provides insight on the design and optimization of the wearable blood pressure monitor."

Keyword(s)

血壓量測
非侵入式
穿戴式裝置
快速傅立葉轉換
雷射都卜勒流速計
PTT
解相技術
電子斑點干涉術
投影式疊紋量測
blood pressure monitor
non-invasive
wearable device
FFT
laser Doppler flowmeter
PTT
phase unwrapping
projection moiré

DSpace CRIS

Doppler Blood Flow Meter Development and Superficial Artery Vibration Measurement by Espi &Amp; Projection Morie

基本資料

Description