An Interactive System for Human Liver and Kidney Organs and Protein Structure 3D Printing with Optimal Support Locations( I )

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Project title

Code/計畫編號

MOST104-2218-E019-003

Translated Name/計畫中文名

具支撐最佳化功能之人體肝腎器官與蛋白質結構3D列印互動系統平台開發( I )

Funding Organization/主管機關

National Science and Technology Council

Co-Investigator(s)/共同執行人

謝君偉(計畫主持人)
李建宏
白敦文
林志郎

Department/Unit

Department of Computer Science and Engineering

Website

https://www.grb.gov.tw/search/planDetail?id=11605813

Year

2015

Start date/計畫起

01-11-2015

Expected Completion/計畫迄

31-10-2016

Co-Investigator(s)

Shyi-Chyi Cheng
Shyh-Kuang Ueng
Haw-Yun Shin

Bugetid/研究經費

4372千元

ResearchField/研究領域

資訊科學--軟體

台灣肝癌與腎病人口眾多，對於肝功能可以透過血液檢查來計算肝發炎指數，對於腎則可透過肌肝酸換算成EGFR，來判定慢性腎功能的期數(stage)，對於肝或腎的腫瘤檢測，判定是否為良性或惡性，是否進一步演變成肝癌或腎癌，現有的方法都需要做生理切片檢查，這對病人的身體有極大的傷害；除此之外，人隨著老化，肝或等器官會逐漸出現水泡，隨著年紀而逐漸變大，往往會壓迫到其他組織或器官如脾臟，甚至變形；另一方面當肝功能或腎功能惡化，往往這些器官的内部組織都會逐漸纖維化，這些纖維化表現從超音波影像中常常難以察覺或分析，為了想精確的分析與判斷病人的器官腫瘤或組織情況，醫生往往需傷透腦筋；另一方面，癌症或腫瘤的發生通常會有家族遺傳性的因素，因為如果能透過蛋白分子結構的檢測，往往能發現問題所在，且能應用生技醫學製藥上面，由於蛋白質的功能與其結構息息相關，蛋白質立體結構的解析資訊，利用3D列印對了解該蛋白質的功能可以提供最直接的說明。此整合計晝的總目標期望發展出一個具支撐最佳化功能之人體肝腎器官微組織與蛋白質結構3D列印系統平台開發，透過此系統，不只是單純3D列印功能，藉由一些記號標示能進一步分析肝腎微血管組織是否病變，且能對蛋白質結構3D作分析為台灣製藥產業做出貢獻。整個總計劃分為四項子計晝，第一子項計晝主要針對人體肝腎器官微組織與蛋白質結構3D列印，所需要的問題做技術開發，包括CT醫學影像肝腎物器官偵測與切割、3D建模、腫瘤3D模型比對與查詢、肝腎器官塑模與列印等；第二子項計晝則針對蛋白質3D結構列印會產生的問題，作解決，包括設計開發列印具有懸空的蛋白質結構模型知支撐功能的核心模組、網格資訊制定與自動輸出等功能；第三子項計晝，則針對目前大部分的3D列印系統，只能讀入STL(STereoLithography)格式檔與參數曲面模型的問題做改進，它無法驅動列印機3維掃瞄點陣列資料和醫學影像中的曲面或實體，企圖建立一個以體像素(Volume)為基礎的3D列印處理平台，並對支撐骨架最佳化分析；第四項子計晝則針對現有的3D列印模擬器只能提供2D俯視圖，沒有厚度感與各角度的透視圖，透過立體標示，能快速找出錯誤並修正，將積層列印產生的鋸齒紋路更加細緻化。為驗證本研究團隊所開發的核心模組之可實用性，本計晝選擇應用在人體肝腎器官分析與藥物研究開發的分子結構列印。由於分子結構的線性鏈狀骨架及構型摺疊的多樣性，特別具有全域性的懸空特徵，因此我們也將強化支撐結構列印的核心技術開發，克服以往單純使用電腦模擬開發的盲點。 The population of patients with liver cancer and kidney disease is huge and increasing soon. The method to identify liver and kidney tumors needs to various slices of liver tissue or kidney tissue which will lead to great harm to patients. In addition, when people are getting older, their liver or kidney organs will appear cysts which will grow according to ages and make some damages or deformations to other organs such as spleen. On the other hand, when live or kidney function deteriorates, their internal organization will gradually become fibrosis. The fibrosis tissue is not easy to be detected from Ultrasound images and makes doctors take headache. In real cases, organ tumor or cancers happens often due to hereditary factors and can be detected by examining molecular structures of protein. The usage of 3D printing can provide important visual information for finding and understanding of liver’s or kidney’s microstructures and the protein’s function and then giving reasonable explanations for tumor or cancers. More importantly, the usage of 3D printing in examining molecular structures of protein can speed up the process of medicine pharmaceutical product development. The overall goal of this project is to develop an interactive platform for 3D printing system with the best topology of support points to print 3D structures of human liver and kidney organ tissues and molecular structures of protein. This system owns not just a simple 3D printing capabilities, with some marks but also to further analyze whether the liver and kidney tumor disease happen. It also can make contributions on Taiwan's pharmaceutical industry by examining the 3D molecular microstructures of proteins. The whole project is divided into four sub-projects. The first sub-project focuses on 3D printing for human liver tissue and organ micro protein structure. The technical research problems includes liver and kidney segmentation from CT medical images, 3D modeling of the tumor, printing, and diagnosis. The second subproject plans for protein 3D structure printing. Its research problems include the design and development of 3D printing system with functions for finding support points, automatic output function for 3D grid structure, and etc. The third sub-project improves the problems in most of current 3D printing systems which can accept only the STL (STereoLithography) format files without optimum finding ability for support points. It attempts to establish a voxel-based 3D printing processing platform with best supporting skeleton analysis. The last child project tries to build a 3D printing simulator with 3D marking function. It can provide various perspective views of thickness structure of the printed object from each viewpoint. Through the 3D marking process, you can quickly find and fix printing errors in time to reduce jagged lines in the final product as can as possible. Finally, this project selects the applications in human liver and kidney organs printing analysis and drug research and development.

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An Interactive System for Human Liver and Kidney Organs and Protein Structure 3D Printing with Optimal Support Locations( I )

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