http://scholars.ntou.edu.tw/handle/123456789/10008
標題: | Liquid Chromatography-Tandem Mass Spectrometry Determination of the Toxicity and Identification of Fish Species in a Suspected Tetrodotoxin Fish Poisoning | 作者: | YA-JUNG WU YING-JU CHENG HSIAO-CHIN JEN CHIH-HSIN PAN TZU-CHUN LIN SHIN-JUNG LIN Deng-Fwu Hwang |
公開日期: | 五月-2011 | 出版社: | International Association for Food Protection | 卷: | 74 | 期: | 5 | 起(迄)頁: | 789-795 | 來源出版物: | Journal of Food Protection | 摘要: | Suspected tetrodotoxin (TTX) poisoning was associated with eating unknown fish in April 2009 in Taiwan. After ingestion of the fish, symptoms of the victim included perioral paresthesia, nausea, vomiting, ataxia, weakness of all limbs, respiration failure, and death within several hours. The toxicity in the remaining fish was determined, with the mice exhibiting symptoms of neurotoxin poisoning. The implicated fish and deceased victim tissues were analyzed for TTX by liquid chromatography–tandem mass spectrometry. The urine, bile, cerebrospinal fluid (spinal cord), pleural effusion, and pericardial effusion of the victim contained TTX. In addition, the partial cytochrome b gene of the implicated fish was determined by PCR. The DNA sequence in the partial 465-bp cytochrome b gene identified the implicated fish as Chelonodon patoca (puffer fish). These results indicate that people should avoid eating unknown fish species from fish markets where harvested fish may include toxic species. |
URI: | http://scholars.ntou.edu.tw/handle/123456789/10008 | ISSN: | 0362-028X | DOI: | 10.4315/0362-028x.Jfp-10-435 |
顯示於: | 食品科學系 |
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