http://scholars.ntou.edu.tw/handle/123456789/17288
Title: | Natural polyketide 6-pentyl-2H-pyrone-2-one and its synthetic analogues efficiently prevent marine biofouling | Authors: | Khan, Mo Aqib Raza Wang, Bo-Wei Chen, Yih-Yu Lin, Ting-Hsuan Lin, Hsiu-Chin Yang, Yu-Liang Pang, Ka-Lai Liaw, Chih-Chuang |
Keywords: | Marine-derived fungi;secondary metabolites;synthetic pyrones;antifouling agents;antimicrobial activity;anti-biofilm formation | Issue Date: | 16-Mar-2021 | Publisher: | TAYLOR & FRANCIS LTD | Journal Volume: | 37 | Journal Issue: | 3 | Start page/Pages: | 257-266 | Source: | BIOFOULING | Abstract: | Biofouling is a widespread phenomenon in oceans worldwide. With increasing human development and activities in open and coastal waters, and due to the environmental impact of AF organotins and copper-based paint, the demand for nontoxic antifouling (AF) paints is increasing. Various bioassays for antimicrobial activity, anti-biofilm formation and anti-barnacle settlement were established to evaluate the possibility of using marine natural products as AF agents. A series of natural products, isolated from the marine-derived fungi Trichoderma atroviride and T. reesei, were evaluated for their AF activity. One pyrone-type compound (1) demonstrated significant inhibitory activities toward barnacle cyprid settlement. Furthermore, a series of pyrone analogues (S1-S6) were synthesized, and their bioactivities were evaluated in the established systems. The results showed that compounds S5 and S6 exhibited a broad spectrum of bioactivities, such as anti-barnacle settlement, anti-biofilm formation and antimicrobial activities. |
URI: | http://scholars.ntou.edu.tw/handle/123456789/17288 | ISSN: | 0892-7014 | DOI: | 10.1080/08927014.2021.1890043 |
Appears in Collections: | 海洋生物研究所 14 LIFE BELOW WATER 15 LIFE ON LAND |
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