http://scholars.ntou.edu.tw/handle/123456789/17472
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Wu, Po-Chang | en_US |
dc.contributor.author | Lin, Shih-Chao | en_US |
dc.contributor.author | Panny, Lauren | en_US |
dc.contributor.author | Chang, Yu-Kang | en_US |
dc.contributor.author | Lin, Chi-Chien | en_US |
dc.contributor.author | Tung, Yu-Tang | en_US |
dc.contributor.author | Chang, Hen-Hong | en_US |
dc.date.accessioned | 2021-08-05T02:15:02Z | - |
dc.date.available | 2021-08-05T02:15:02Z | - |
dc.date.issued | 2021-06 | - |
dc.identifier.issn | 2075-1729 | - |
dc.identifier.uri | http://scholars.ntou.edu.tw/handle/123456789/17472 | - |
dc.description.abstract | Sjogren's syndrome (SS) is an inflammatory autoimmune disease primarily affecting the exocrine glands; it has a major impact on patients' lives. The Chinese herbal formula SS-1 is composed of Gan Lu Yin, Sang Ju Yin, and Xuefu Zhuyu decoction, which exerts anti-inflammatory, immunomodulatory, and antifibrotic effects. Our previous study demonstrated that SS-1 alleviates clinical SS. This study aimed to evaluate the efficacy and mechanism of the Chinese herbal formula SS-1 for salivary gland protein-induced experimental Sjogren's syndrome (ESS). These results showed that ESS treatment with the Chinese herbal formula SS-1 (1500 mg/kg) significantly alleviated the severity of ESS. We found that SS-1 substantially improved saliva flow rates in SS mice and ameliorated lymphocytic infiltrations in submandibular glands. In addition, salivary gland protein-induced SS in mice treated with SS-1 significantly lowered proinflammatory cytokines (including IFN-gamma, IL-6, and IL-17A) in mouse salivary glands and decreased serum anti-M3R autoantibody levels. In addition, we found that CD4+ T cells isolated from SS-1-treated SS mice significantly reduced the percentages of IFN-gamma-producing CD4+ T cells (Th1) and IL-17A-producing CD4+ T cells (Th17). Our data show that SS-1 alleviates ESS through anti-inflammatory and immunomodulatory effects, which provides new insight into the clinical treatment of SS. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | MDPI | en_US |
dc.relation.ispartof | LIFE-BASEL | en_US |
dc.subject | SYSTEMIC-LUPUS-ERYTHEMATOSUS | en_US |
dc.subject | MOUSE MODEL | en_US |
dc.subject | CELLS | en_US |
dc.subject | DIFFERENTIATION | en_US |
dc.subject | AUTOANTIBODIES | en_US |
dc.subject | ANTIBODIES | en_US |
dc.title | Effect of the Chinese Herbal Medicine SS-1 on a Sjogren's Syndrome-Like Disease in Mice | en_US |
dc.type | journal article | en_US |
dc.identifier.doi | 10.3390/life11060530 | - |
dc.identifier.isi | WOS:000667404600001 | - |
dc.relation.journalvolume | 11 | en_US |
dc.relation.journalissue | 6 | en_US |
item.cerifentitytype | Publications | - |
item.grantfulltext | none | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.fulltext | no fulltext | - |
item.languageiso639-1 | en_US | - |
crisitem.author.dept | College of Life Sciences | - |
crisitem.author.dept | Bachelor Degree Program in Marine Biotechnology | - |
crisitem.author.dept | National Taiwan Ocean University,NTOU | - |
crisitem.author.orcid | 0000-0003-2942-5937 | - |
crisitem.author.parentorg | National Taiwan Ocean University,NTOU | - |
crisitem.author.parentorg | College of Life Sciences | - |
顯示於: | 海洋生物科技學士學位學程(系) 03 GOOD HEALTH AND WELL-BEING |
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