http://scholars.ntou.edu.tw/handle/123456789/17472
Title: | Effect of the Chinese Herbal Medicine SS-1 on a Sjogren's Syndrome-Like Disease in Mice | Authors: | Wu, Po-Chang Lin, Shih-Chao Panny, Lauren Chang, Yu-Kang Lin, Chi-Chien Tung, Yu-Tang Chang, Hen-Hong |
Keywords: | SYSTEMIC-LUPUS-ERYTHEMATOSUS;MOUSE MODEL;CELLS;DIFFERENTIATION;AUTOANTIBODIES;ANTIBODIES | Issue Date: | Jun-2021 | Publisher: | MDPI | Journal Volume: | 11 | Journal Issue: | 6 | Source: | LIFE-BASEL | Abstract: | Sjogren's syndrome (SS) is an inflammatory autoimmune disease primarily affecting the exocrine glands; it has a major impact on patients' lives. The Chinese herbal formula SS-1 is composed of Gan Lu Yin, Sang Ju Yin, and Xuefu Zhuyu decoction, which exerts anti-inflammatory, immunomodulatory, and antifibrotic effects. Our previous study demonstrated that SS-1 alleviates clinical SS. This study aimed to evaluate the efficacy and mechanism of the Chinese herbal formula SS-1 for salivary gland protein-induced experimental Sjogren's syndrome (ESS). These results showed that ESS treatment with the Chinese herbal formula SS-1 (1500 mg/kg) significantly alleviated the severity of ESS. We found that SS-1 substantially improved saliva flow rates in SS mice and ameliorated lymphocytic infiltrations in submandibular glands. In addition, salivary gland protein-induced SS in mice treated with SS-1 significantly lowered proinflammatory cytokines (including IFN-gamma, IL-6, and IL-17A) in mouse salivary glands and decreased serum anti-M3R autoantibody levels. In addition, we found that CD4+ T cells isolated from SS-1-treated SS mice significantly reduced the percentages of IFN-gamma-producing CD4+ T cells (Th1) and IL-17A-producing CD4+ T cells (Th17). Our data show that SS-1 alleviates ESS through anti-inflammatory and immunomodulatory effects, which provides new insight into the clinical treatment of SS. |
URI: | http://scholars.ntou.edu.tw/handle/123456789/17472 | ISSN: | 2075-1729 | DOI: | 10.3390/life11060530 |
Appears in Collections: | 海洋生物科技學士學位學程(系) 03 GOOD HEALTH AND WELL-BEING |
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