|Title:||R-Phycoerythrin from Colaconema formosanum (Rhodophyta), an Anti-Allergic and Collagen Promoting Material for Cosmeceuticals||Authors:||Lee, Po-Tsang
|Keywords:||cosmetic;Colaconema formosanum;R-phycoerythrin;anti-allergy;anti-aging||Issue Date:||1-Oct-2021||Publisher:||MDPI||Journal Volume:||11||Journal Issue:||20||Source:||APPLIED SCIENCES-BASEL||Abstract:||
R-phycoerythrin (R-PE), a pigment complex found in red algae, was extracted and purified from a newly identified red alga, Colaconema formosanum, and its bioactivities were examined. It was revealed that R-PE treatment resulted in high cell viability (> 70%) to the mammalian cell lines NIH-3T3, RBL-2H3, RAW264.7, and Hs68, and had no effect on cell morphology in NIH-3T3 cells. Its suppression effect was insignificant on the production of IL-6 and TNF-alpha in lipopolysaccharides-stimulated RAW264.7 cells. However, calcium ionophore A23187-induced beta-hexosaminidase release was effectively inhibited in a dose-dependent manner in RBL-2H3 cells. Additionally, it was revealed to be non-irritating to bionic epidermal tissues. Notably, procollagen production was promoted in Hs68 cells. Overall, the data revealed that R-PE purified from C. formosanum exhibits anti-allergic and anti-aging bioactivities with no observed consequential toxicity on multiple mammalian cell lines as well as epidermal tissues, suggesting that this macromolecule is a novel material for potential cosmetic use.
|Appears in Collections:||水產養殖學系|
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