http://scholars.ntou.edu.tw/handle/123456789/20397
標題: | Functional components in Scutellaria barbata D. Don with anti-inflammatory activity on RAW 264.7 cells | 作者: | Liu, Hsin-Lan Kao, Tsai-Hua Shiau, Chyuan-Yuan Chen, Bing-Huei |
關鍵字: | LIPOPOLYSACCHARIDE-STIMULATED MACROPHAGES;PRESSURE CHEMICAL-IONIZATION;PHOTODIODE ARRAY DETECTION;NF-KAPPA-B;MASS-SPECTROMETRY;CHLOROPHYLL-A;ANTIOXIDANT ACTIVITY;FLAVONOIDS;EXTRACTS;PHEOPHYTIN | 公開日期: | 一月-2018 | 出版社: | FOOD & DRUG ADMINSTRATION | 卷: | 26 | 期: | 1 | 起(迄)頁: | 31-40 | 來源出版物: | J FOOD DRUG ANAL | 摘要: | The objectives of this study were to determine the variety and amount of various functional components in Scutellaria barbata D. Don as well as study their anti-inflammatory activity on RAW 264.7 cells. Both ethanol and ethyl acetate extracts were shown to contain the functional components including phenolics, flavonoids, chlorophylls, and carotenoids, with the former mainly composed of phenolics and flavonoids, and the latter of carotenoids and chlorophylls. Both extracts could significantly inhibit (p < 0.05) the production of lipopolysaccharide-induced nitric oxide, prostaglandin E-2, interlukin-6, and interlukin-1 beta, as well as the expressions of phosphor extracellular signal-regulated kinase and phosphor-c-Jun N-terminal kinase (p-JNK), but failed to retard tumor necrosis factor-alpha expression. Both ethanol and ethyl acetate extracts had a dose-dependent anti-inflammatory activity on RAW 264.7 cells. Furthermore, the anti-inflammatory efficiency can be varied for both ethanol and ethyl acetate extracts, which can be attributed to the presence of different varieties and amounts of functional components, as mentioned above. This finding suggested that S. Barbata extract may be used as an anti-inflammatory agent for possible future biomedical application. Copyright (C) 2017, Food and Drug Administration, Taiwan. Published by Elsevier Taiwan LLC. |
URI: | http://scholars.ntou.edu.tw/handle/123456789/20397 | ISSN: | 1021-9498 | DOI: | 10.1016/j.jfda.2016.11.022 |
顯示於: | 03 GOOD HEALTH AND WELL-BEING |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。