http://scholars.ntou.edu.tw/handle/123456789/24649
標題: | Fucoidan from<i> Cladosiphon</i><i> okamuranus</i> enhances antioxidant activity and prevents reproductive dysfunction in polystyrene microplastic-induced male rats | 作者: | Hwang, Yi-Yuh Sudirman, Sabri Wei, En-Yu Kong, Zwe-Ling Hwang, Deng-Fwu |
關鍵字: | Antioxidants;Fucoidan;Microplastic;Reproductive function | 公開日期: | 2024 | 出版社: | ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER | 卷: | 170 | 來源出版物: | BIOMEDICINE & PHARMACOTHERAPY | 摘要: | Plastic pollution, including microplastic, has emerged as a severe environmental and public health problem. The health risks, especially in the case of reproductive damage caused by polystyrene microplastic (PS-MP) exposure, are emerging problems that need to be solved. This study aimed to investigate the effects of fucoidan extracted from Cladosiphon okamuranus on the polystyrene microplastic-induced oxidative stress of the Leydig (LC540) cells and reproductive damage in male rats. The oxidative stress of the LC540 cells and reproductive damage in the rats were induced by PS-MP. The fucoidan treatment reduces nitric oxide (NO) and reactive oxygen species generation in the LC540 cells. In the animal study, fucoidan treatment enhanced enzymatic antioxidant activities (glutathione peroxidase, superoxide dismutase, glucose-6-phosphate dehydrogenase, and glutathione reductase) and reduced malondialdehyde and nitric oxide production. Fucoidan supplementation also downregulates tumor necrosis factor-alpha, interleukin-6, and caspase-3 expression. Additionally, fucoidan upregulates testosterone levels, prevents the reduction of epithelium thickness, and reduces the area of the seminiferous tubule lumen. According to these conditions, fucoidan from Cladosiphon okamuranus prevents reproductive damage by downregulating oxidative stress and pro-inflammatory cytokines. Therefore, fucoidan can be used as a source of food supplements or functional food ingredients for reproductive or testicular damage management. |
URI: | http://scholars.ntou.edu.tw/handle/123456789/24649 | ISSN: | 0753-3322 | DOI: | 10.1016/j.biopha.2023.115912 |
顯示於: | 食品科學系 |
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