http://scholars.ntou.edu.tw/handle/123456789/5489
標題: | Taurine prevented cell cycle arrest and restored neurotrophic gene expression in arsenite-treated SH-SY5Y cells | 作者: | Chien-Te Chou Wen-Feng Lin Zwe-Ling Kong Shiow-Yi Chen Deng-Fwu Hwang |
關鍵字: | Arsenite;Taurine;NDRG-4;BDNF;SIRT-1;Neurotrophic | 公開日期: | 7-六月-2013 | 出版社: | Springer | 卷: | 45 | 期: | 4 | 起(迄)頁: | 811-819 | 來源出版物: | Amino Acids | 摘要: | The study investigated the effect of taurine on cell viability and neurotrophic gene expression in arsenite-treated human neuroblastoma SH-SY5Y cells. Arsenite-induced intracellular reactive oxygen species (ROS) and interrupted cell cycle in SH-SY5Y cells. In addition, arsenite reduced mitochondria membrane potential (MMP) and decreased neurotrophic gene expressions such as n-myc downstream-regulated gene 4 (NDRG-4), brain-derived neurotrophic factor (BDNF) and sirtuin-1 (SIRT-1) in SH-SY5Y cells. In parallel, taurine prevented cell cycle, restored MMP and reduced the intracellular ROS level, and taurine recovered NDRG-4, BDNF and SIRT-1 gene expressions in arsenite-treated SH-SY5Y cells while taurine alone has no effect on these parameters. |
URI: | http://scholars.ntou.edu.tw/handle/123456789/5489 | ISSN: | 0939-4451 | DOI: | 10.1007/s00726-013-1524-y |
顯示於: | 生命科學暨生物科技學系 |
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