http://scholars.ntou.edu.tw/handle/123456789/6090
標題: | Evaluation of the epinecidin-1 peptide as an active ingredient in cleaning solutions against pathogens | 作者: | Chieh-Yu Pan Venugopal Rajanbabu Jyh-Yih Chen Guor Mour Her Fan-Hua Nan |
公開日期: | 八月-2010 | 卷: | 31 | 期: | 8 | 起(迄)頁: | 1449-58. | 來源出版物: | Peptides | 摘要: | We tested the activity of epinecidin-1, a novel antimicrobial peptide structurally related to pleurocidin, in commercial cleaning solutions stored at 4 and 25 degrees C for 7 and 14 days. The peptide's activities against Enterococcus faecalis, Escherichia coli, Klebsiella oxytoca, Pseudomonas aeruginosa, Staphylococcus aureus, Propionibacterium acnes, and Candida albicans were measured in a minimum inhibitory concentration (MIC) determination, minimal bactericidal concentration (MBC) determination, disk diffusion test, and a count of the bacterial numbers. Exposure to epinecidn-1 in a cleaning solution following MIC value comparisons in the disk diffusion test and counts of bacterial numbers after 16, 24, 48, and 72 h suggested that bacterial numbers were much lower than those treated with only commercial cleaning solutions for all bacteria. The efficacy of the antimicrobial activities of inhibiting bacterial numbers by epinecidin-1 in cleaning solutions at a low pH and a low temperature was not affected. Given its simple structure and antimicrobial activity, epinecidin-1 may be a useful component of microbicides designed to prevent pathogen infections and/or remediate abnormal vaginal or skin flora. |
URI: | http://scholars.ntou.edu.tw/handle/123456789/6090 | ISSN: | 0196-9781 | DOI: | 10.1016/j.peptides.2010.05.011 |
顯示於: | 水產養殖學系 |
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