http://scholars.ntou.edu.tw/handle/123456789/6101
標題: | Over-inhibition of NADPH oxidase reduce the wound healing in liver of finfish | 作者: | Yu-Sheng Wu Shih-Ling Huang Fan-Hua Nan Ching-Sheng Chang Chien-Mei Hsiao Kam-Chiu Lai Shiu-Nan Chen |
關鍵字: | Histopathology;Hydrogen peroxide;NADPH oxidase;Partial hepatectomy;Repair | 公開日期: | 九月-2014 | 卷: | 40 | 期: | 1 | 起(迄)頁: | 174-81 | 來源出版物: | Fish & Shellfish Immunology | 摘要: | Wound healing is a complex process involving soluble mediators, blood cells, extracellular matrix, and parenchymal cells in a response that occurs after surgical procedure or traumatic injury. The present study aims to investigate the ROS producing from the injury that involved in the wound healing using the ZFL (zebrafish liver cell) and tilapia partial hepatectomy model. In the ZFL, we observed that while over-inhibition of NADPH activity leading to reduce the wound healing moreover, experiment of the oxidative stress by the extracellular hydrogen peroxide exactly presented to increase the PCNA, BrdU and Ki-67 histopathological repair response of tilapia liver follow partial hepatectomy. We conclude that over inhibition of the NADPH oxidase by DPI may reduce the cell even the tissue in the progress of healing after the injury. |
URI: | http://scholars.ntou.edu.tw/handle/123456789/6101 | ISSN: | 1050-4648 | DOI: | 10.1016/j.fsi.2014.06.028 |
顯示於: | 水產養殖學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。