http://scholars.ntou.edu.tw/handle/123456789/9031
標題: | Peptides from hydrolysate of lantern fish (Benthosema pterotum) proved neuroprotective in vitro and in vivo | 作者: | Chai, Huey-Jine Wu, Chang-Jer Yang, Shu-Han Li, Tsung-Lin Pan, Bonnie Sun |
關鍵字: | GERMINATED BROWN RICE;NEUROTROPHIC FACTOR;OXIDATIVE STRESS;CELL-DEATH;MEMORY;RAT;IMPAIRMENT;DISEASE;ACID | 公開日期: | 六月-2016 | 出版社: | ELSEVIER | 卷: | 24 | 起(迄)頁: | 438-449 | 來源出版物: | J FUNCT FOODS | 摘要: | Benthosema pterotum is an underutilized deep-sea by-catch fish. Its protein hydrolysate (BPH) showed antioxidative activity. The BPH consisting of 13.2 mg/g of active peptides, Phe-Tyr-Tyr and Asp-Trp, significantly reduced H2O2-induced reactive oxygen species (ROS) and apoptotic cell death in human neuroblastoma SH-SY5Y cells through activation of intracellular antioxidant defence system. In Morris water-maze test, BPH was able to ameliorate memory and learning deficiency of D-galactose (D-gal)-induced neurodegenerative/ageing ICR mice. BPH-fed mice showed significantly lower levels of both D-gal-induced thiobarbituric acid reactive substances (TBARS) and endothelial nitric oxide synthase (eNOS), but higher levels of glucose-6-phosphate dehydrogenase (G6PDH) and brain-derived neurotrophy factor (BDNF) in brain of ageing mice in comparison to the control. In light of these results, BPH may be considered as a novel nutraceutical for easing the ageing and/or age-related neurodegenerative diseases. (C) 2016 Elsevier Ltd. All rights reserved. |
URI: | http://scholars.ntou.edu.tw/handle/123456789/9031 | ISSN: | 1756-4646 | DOI: | 10.1016/j.jff.2016.04.009 |
顯示於: | 食品科學系 03 GOOD HEALTH AND WELL-BEING |
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