http://scholars.ntou.edu.tw/handle/123456789/9819
Title: | Lactobacillus reuteri induces intestinal immune tolerance against food allergy in mice | Authors: | Chung-Hsiung Huang Yu-Chin Lin Tong-Rong Jan |
Keywords: | Food allergy;Lactobacillus reuteri;Regulatory T cell;Tolerogenic dendritic cell | Issue Date: | Apr-2017 | Publisher: | Elsevier | Journal Volume: | 31 | Start page/Pages: | 44-51 | Source: | Journal of Functional Foods | Abstract: | The effect of Lactobacillus reuteri against food allergy was investigated in ovalbumin (OVA)-sensitized BALB/c mice. Oral administration with L. reuteri restored the deteriorated profile of enteric flora, and attenuated allergic diarrhoea, mast cell activation, and serum IgE production in allergic mice. The production of signature T helper (Th)1 and 2 cytokines, namely IFN-γ and IL-4, by splenocytes was suppressed by L. reuteri. Concordantly, the intestinal expression of IFN-γ, IL-4, T-bet and GATA3 was down-regulated. However, L. reuteri augmented the expression of IL-10, TGF-β and Foxp3, and the number of IL-10-secreting CD11c+CD103+ mesenteric lymph node (MLN) cells. Furthermore, direct exposure to heat-killed L. reuteri attenuated OVA-induced cell proliferation and IL-2 secretion by MLN cells. These results demonstrate that L. reuteri possesses anti-allergic activities via modulating enteric flora and promoting tolerogenic immune responses, and suggest L. reuteri as a functional probiotic against food allergy. |
URI: | http://scholars.ntou.edu.tw/handle/123456789/9819 | ISSN: | 1756-4646 | DOI: | 10.1016/j.jff.2017.01.034 |
Appears in Collections: | 食品科學系 |
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