Development of Oral Vaccine against Grouper Iridovirus of Taiwan (II) Immunomodulation by Feed Supplements in Grouper

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Project title

Code/計畫編號

94農科-5.1.6-漁-F1(4)

Translated Name/計畫中文名

石斑虹彩病毒口服疫苗之開發研究(二)---飼料添加物之免疫功能評估

Project Coordinator/計畫主持人

Hsin-Yiu Chou

Funding Organization/主管機關

Council of Agriculture,Executive Yuan

Department/Unit

Department of Aquaculture

Website

https://www.grb.gov.tw/search/planDetail?id=1156818

Year

2005

Start date/計畫起

01-01-2005

Expected Completion/計畫迄

31-12-2005

Bugetid/研究經費

650千元

ResearchField/研究領域

漁業

疫苗開發雖是解決魚類病毒性疾病的重要防治對策之一，但如成本偏高、施用方式的選擇、以及緊迫與有效性等問題仍待解決，因此目前只有極少數的疫苗成為商品化。本研究室針對台灣石斑虹彩病毒 (grouper iridovirus of Taiwan，簡稱TGIV) 發展出具良好保護效果之不活化疫苗，微米膠囊疫苗的餵食石斑魚的保護效果達67%，較未包埋處理組疫苗的保護效果提高近30%。可是奈米膠囊疫苗效果不盡理想，顯示口服疫苗具開發潛力，但是包埋處理方式有持續探討的必要性。本年度希望改良微膠囊包埋技術，同時探討輔助飼料對魚體抗病能力之影響後，添加輔助飼料強化疫苗的保護效果，製備出具良好保護效果之虹彩病毒口服疫苗。 Vaccine development is one of the major approaches of controlling viral diseases in aquaculture. Unfortunately, in consideration of detailed items of vaccination, such as cost, stress and efficacy, there are only a few of commercially available vaccines for fish viral pathogens to date. We have developed an inactivated vaccine against grouper iridovirus of Taiwan (TGIV). In our forward project, microencapsulated TGIV vaccine was mixed with eel feed meal to immunized grouper orally and protection rate reached 67%. Even though only 10% protection rate was obtained in the nanoencapsulated TGIV vaccine group. The comparative results of vaccine without and with encapsulation showed that encapsulated treatment could aid to improve the efficacy of vaccination in the route of oral administration. To aim at practical uses of the TGIV vaccine, improvement of encapsulation way is claim attention in this project. Moreover, in combination of vaccine and dietary supplementation may be effective mean of increasing potency of vaccine to resist viral infection. Therefore, present study will conduct to develop encapsulated oral vaccine for practicable use of TGIV vaccine and control of the disease.

Keyword(s)

石斑魚
虹彩病毒
口服疫苗
飼料添加物
免疫調節功能
Grouper
Iridovirus
Oral Vaccine
Feed Supplement
Immunomodulation

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Development of Oral Vaccine against Grouper Iridovirus of Taiwan (II) Immunomodulation by Feed Supplements in Grouper

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