Design of New Nano-Porous Material Try to Emulated Nature's Open Framework in Organic/Inorganic Hybrid Complex and Their Application

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Project title

Code/計畫編號

NSC94-2614-B019-001

Translated Name/計畫中文名

師法生命現象自組裝原理開發新穎金屬有機無機複合之奈米孔洞材料與應用

Project Coordinator/計畫主持人

Hsiu-Mei Lin

Funding Organization/主管機關

National Science and Technology Council

Department/Unit

Department of Bioscience and Biotechnology

Website

https://www.grb.gov.tw/search/planDetail?id=1148396

Year

2005

Start date/計畫起

01-08-2005

Expected Completion/計畫迄

31-07-2006

Bugetid/研究經費

550千元

ResearchField/研究領域

醫學工程

" 利用生物分子之自動組合(self-assembly)的構想，以固態合成法開發金屬platin材料；可以此奈米孔洞為載體，放入platin抗癌藥物，研究此藥物在MCM-41內釋放速率，以MBT-2膀胱癌細胞株為對象，研究MCM-41內platin的DNA damage程度。此研究計劃的目標如下: 1. 開發、合成新穎platin化合物。 2. 測試MCM-41材質本身的細胞毒性以及在細胞內部分佈的情形。 3. 抗癌藥cis-platin放入MCM-41內部，並測量MCM-41釋放platin 的速率。 4. 以MBT-2膀胱癌細胞株為對象，瞭解platin放入MCM-41內後其DNA damage的程度變化。 " " This project uses the concept of self-assembly of bio-molecules to design platin materials by solid state synthesis. Nano-pore materials can be used as drug carrier for the anti-tumor platin complex, and the delivery rate of platin within the mobile crystalline material MCM-41 can be studied. This research focuses on the treatment of MBT-2 bladder cancer cells with the anti-tumor drug platin delivers by MCM-41, and the degree of DNA damage by platin/MCM-41 within the cells is studied. Research proposals: 1. To design and synthesize new platin materials. 2. To study the toxicity and distribution of MCM-41 within cells. 3. To study the delivery rate of the anti-tumor drug platins within MCM-41 carrier. 4. To study the degree of DNA cell damage by platins/MCM-41 in the treatment of MBT-2 bladder cancer cells. "

Keyword(s)

固態化學
水熱合成
孔洞材料
抗癌藥物platin
藥物釋放
Solid state chemistry
hydrothermal synthesis
platin
nano-pore materials
drug delivery

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Design of New Nano-Porous Material Try to Emulated Nature's Open Framework in Organic/Inorganic Hybrid Complex and Their Application

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