Molecular Study of Antitumor Factor in Hard Clam Involved to Apoptosis of Tumor Cells

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Project title

Code/計畫編號

NSC87-2313-B019-051

Translated Name/計畫中文名

文蛤抗腫瘤因子的分子構造與癌細胞程式死亡

Project Coordinator/計畫主持人

Zwe-Ling Kong

Funding Organization/主管機關

National Science and Technology Council

Department/Unit

Department of Food Science

Website

https://www.grb.gov.tw/search/planDetail?id=343379

Year

1998

Start date/計畫起

01-08-1997

Expected Completion/計畫迄

01-07-1998

Bugetid/研究經費

801千元

ResearchField/研究領域

生物科學

Nondialyzable fraction of hot-water extracts of hard clam, Meretrix lusoria act as an apoptotic factor to hepatoma, HepG2 and Hep3B, and especially toward hepatoblastoma, HuH-6KK cells. Such hot water extracts showed strong cell aggluting and stimulating activity on cultured U-M, HB4C5, and SI102 cells but not on U937 or HL60 cells. Telomerase activity is involved in telomere length maintenance and known as a ribonucleoprotein which synthesizes telomere repeats onto chromosome ends. We also found telomerase activity decreasing in dose dependency. In this project, cellular DNA damage and telomerase activity in the presence of hard clam extract had been studied parallely. Telomerase activity was detected by designed telomere oligonucleotides with PCR amplification and DNA probe technique(TRAP). We also study the expression of antitumor activity toward several cell cultured in different medium condition.

Keyword(s)

文蛤
抗腫瘤因子
細胞程式化死亡
端粒酵素
Hard clain
Antitumor factor
Apoptosis
Telomerase

DSpace CRIS

Molecular Study of Antitumor Factor in Hard Clam Involved to Apoptosis of Tumor Cells

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