Effect of Dietary Crude Adlay on Plasma Glucose and Lipid Levels in Diabetic Rats Induced by Streptozotocin

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Project title

Code/計畫編號

NSC89-2313-B019-015

Translated Name/計畫中文名

糙薏仁影響糖尿病大白鼠血糖及血脂質作用之探討

Project Coordinator/計畫主持人

Meng-Tsan Chiang

Funding Organization/主管機關

National Science and Technology Council

Department/Unit

Department of Food Science

Website

https://www.grb.gov.tw/search/planDetail?id=494641

Year

2000

Start date/計畫起

01-08-1999

Expected Completion/計畫迄

01-07-2000

Bugetid/研究經費

611千元

ResearchField/研究領域

食品科技(農)

本研究目的在於探討糙薏仁對糖尿病大白鼠脂質及糖代謝的影響。以S.D. （Sprague Dawley）系統之雄性大白鼠為實驗動物，由皮下注射streptozotocin (STZ) (60mg/kg B.W.)的方式，以誘發糖尿病。實驗週數為九週，分成三組，分別是(1)Corn starch (2)Dehulled adlay (3)Rice，實驗期間採自由飲水、攝食的方式。實驗結果發現，糙薏仁會降低糖尿病大白鼠中游離脂肪酸的含量及增加脂肪組織重量與體脂比。至於血糖的變化上，在實驗第四週時糙薏仁組明顯比玉米粉組有較低的血糖，但到第九週時血糖仍有下降的趨勢，但在統計上則無顯著差異。從耐糖實驗中亦顯示攝食糙薏仁的糖尿病大白鼠具有良好的耐糖能力。在血漿分析方面，糙薏仁組與精白米組皆較玉米粉組會明顯降低血漿中總膽固醇的含量。三組不同飲食相較之下，以糙薏仁組最能顯著降低VLDL-C+LDL-C的含量，並明顯提高HDL-C/TC的比值。另外，糙薏仁組與精白米組皆同樣會明顯降低血漿中三酸甘油酯含量。而在肝臟方面，無論是攝食糙薏仁或精白米的糖尿病大白鼠都具有較大的肝重，但在肝體比方面三組則無顯著差異，以及明顯增加肝臟中總膽固醇的含量，並且提高肝臟中脂質合成酵素G-6-P DHase的總肝活性。關於糖代謝的影響，攝食糙薏仁的糖尿病大白鼠會顯著降低血漿中乳酸以及肝臟中肝醣的含量，同時顯著提升糖代謝酵素Hexokinase與Phosphofructokinase (PFKase)的總肝活性以及G-6-Pase的比活性。 The purpose of this study was to investigate the effects of dehulled adlay on lipid and carbohydrate metabolism in streptozotocin (STZ)-induced diabetic rats. Male S.D. rats were used as experimental animal model and were made diabetic status by intravenous injection of 60 mg per kg of streptozotocin. The experiment was done for nine weeks and the experimental animals were divided into 3 groups: (1) corn starch (2) dehulled adlay (3) rice. The results of experiment showed that dehulled adlay significantly increased the adipose tissue weight and decreased plasma free fatty acid levels in diabetic rats. In the fourth week, dehulled adlay had lower plasma glucose levels than corn starch groups, but no significant difference was observed among the three dietary groups in the ninth week. The diabetic rats fed dehulled adlay had better ability of glucose tolerance. In addition, dehulled adlay significantly reduced plasma total cholesterol level. Rats fed the dehulled adlay had lower plasma VLDL-C+LDL-C levels,and higher HDL-C/TC ratio. Moreover, significantly decreased plasma triglyceride level were found in dehulled adlay group and rice group. Liver hexokinase, G-6-Pase and PFKase activities was significantly increased in rats fed the dehulled adlay diet, but liver glycogen content was decreased.

Keyword(s)

糙薏仁
糖尿病大白鼠
血脂質
血糖
Adlay
Diabetic rat
Plasma lipid
Plasma glucose

DSpace CRIS

Effect of Dietary Crude Adlay on Plasma Glucose and Lipid Levels in Diabetic Rats Induced by Streptozotocin

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