Effect of Dietary Dehulled Adlay on Plasma Lipids in STZ Induced Diabetic Rats Fed a Diet with or without Cholesterol Supplementation

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Project title

Code/計畫編號

NSC90-2313-B019-044

Translated Name/計畫中文名

膽固醇對糙薏芢降低STZ所引起的糖尿病大白鼠血脂質的影響

Project Coordinator/計畫主持人

Meng-Tsan Chiang

Funding Organization/主管機關

National Science and Technology Council

Department/Unit

Department of Food Science

Website

https://www.grb.gov.tw/search/planDetail?id=648890

Year

2001

Start date/計畫起

01-08-2001

Expected Completion/計畫迄

01-07-2002

Bugetid/研究經費

637千元

ResearchField/研究領域

食品科技(農)

本研究目的在於探討糙薏仁在添加或不添加膽固醇飲食條件下對糖尿病大白鼠血脂質及血糖濃度的影響。以Sprague-Dawley(SD)系統之雄性大白鼠為實驗動物，經皮下注射Streptozotocin(STZ)(60mg/kg B.W.)以誘發糖尿病。實驗共分為四組，分別是(1)Corn starch；(2)Dehulled adlay；(3)Corn starch + 0.5% Cholesterol；(4)Dehulled adlay + 0.5% Cholesterol；實驗共進行六週。實驗結果發現，在不添加膽固醇條件下，糙薏仁飲食會明顯降低血漿總膽固醇、葡萄糖、果糖胺、三酸甘油脂、磷脂質、游離脂肪酸、Apolipoprotein B與β-羥基丁酸的含量。此外，糙薏仁飲食亦會降低血漿極低密度脂蛋白膽固醇及低密度脂蛋白膽固醇含量，而無論飲食中有無膽固醇的添加，攝食糙薏仁飲食後皆有明顯較高的脂肪組織。另一方面，膽固醇的添加會顯著提高血漿總膽固醇、極低密度脂蛋白膽固醇及低密度脂蛋白膽固醇含量，且降低糖尿病大白鼠的體重，但並不影響血糖及三酸甘油脂含量。在添加膽固醇條件下，糙薏仁亦會顯著性降低血漿總膽固醇、極低密度脂蛋白膽固醇、低密度脂蛋白膽固醇、葡萄糖、果糖胺、β-羥基丁酸及游離脂肪酸含量，提高脂肪組織重量。由本研究結果顯示(1)膽固醇的添加可能促進糖尿病大白鼠的脂肪組織分解作用；(2)無論膽固醇添加與否，薏仁可能具有降低糖尿病血脂質及血糖濃度的作用。 To investigate the effect of dietary adlay on plasma lipids and glucose concentrations in diabetic rats fed on a diet with or without cholesterol supplementation, Spreque-Dawley (SD) rats were used as animal model. The diabetic status was induced by subcutaneous injection of streptozotocin (60 mg/kg). All the rats were divided into 4 groups, there are (1) corn starch (CS); (2) Dehulled adlay (DA); (3) corn starch + 0.5% cholesterol (CSC) and (4) Dehulled adlay + 0.5% cholesterol (DAC). The experiment was done for 6 weeks. Lower plasma total cholesterol, triglyceride, phospholipids, glucose, fructosamine, free fatty acid and .beta.-HBA concentrations were observed in rats fed DA diet when compared with those fed the CS diet. Significantly decreased VLDL-cholesterol and LDL-cholesterol was observed in DA group. Cholesterol supplementation significantly dramatically increased plasma total cholesterol, LDL-cholesterol and VLDL-cholesterol but decreased adipose tissue weight in diabetic rats. Adlay supplementation significantly increased adipose tissue weight in diabetic rats fed on a diet with or without cholesterol supplementation. No significant difference in plasma TG and glucose was observed in rats after cholesterol supplementation. In cholesterol supplement groups, lower plasma total cholesterol, LDL-cholesterol, VLDL-cholesterol, glucose, fructosamine, .beta.-HBA, free fatty acid concentration and higher adipose tissue weight were observed in rats after adlay treatment. Results from the present study suggest that (1) cholesterol supplement may promote the lipolysis in diabetic rats; (2) adlay treatment may decrease plasma lipids and glucose concentration in diabetic rats fed on a diet with or without cholesterol supplementation.

Keyword(s)

糙薏仁
膽固醇
血脂質
糖尿病大鼠
Dehulled adlay
Cholesterol
Blood lipid
Diabetic rat

DSpace CRIS

Effect of Dietary Dehulled Adlay on Plasma Lipids in STZ Induced Diabetic Rats Fed a Diet with or without Cholesterol Supplementation

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