Molecular Mechanism on Comparative Effect of High and Low Molecular Weight Chitosan on Reducing Plasma Lipids and Glucose

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基本資料

Project title

Code/計畫編號

MOST106-2320-B019-004

Translated Name/計畫中文名

比較高、低分子量幾丁聚醣降低血糖及血脂的分子機轉

Project Coordinator/計畫主持人

Meng-Tsan Chiang

Funding Organization/主管機關

National Science and Technology Council

Department/Unit

Department of Food Science

Website

https://www.grb.gov.tw/search/planDetail?id=12239516

Year

2017

Start date/計畫起

01-08-2017

Expected Completion/計畫迄

01-07-2018

Bugetid/研究經費

1240千元

ResearchField/研究領域

食品科技(農)

"幾丁聚醣會降低血脂、血糖及抗肥胖，過去幾年我們利用糖尿病動物、高血脂動物及肥胖動物已解開幾丁聚醣降低血糖、血脂及抗肥胖的相關機制，然而在過程中，我們發現不同分子量的幾丁聚醣降低血脂、血糖的效應並不相同。在攝食量相同的情況下，高分子量幾丁聚醣能降低血脂及血糖，但是低分子量的幾丁聚醣只能降低血脂，且高分子量幾丁聚醣較低分子量幾丁聚醣作用更為明顯。此結果顯示不同分子量幾丁聚醣對脂質代謝與糖代謝的影響可能不一樣。推測不同分子量幾丁聚醣可能透過腸道中的MTTP (Microsomal triglyceride transfer protein)及 Angptl 4(Angiopoietin-like proteins 4) 蛋白質表現量不同，以及不同的脂肪酸transporter ( FATP1 和FABP4)表現量來影響脂質吸收，另外不同分子量幾丁聚醣亦可能對肝臟糖新生作用有所不同。因此為瞭解不同分子量幾丁聚醣對血糖及血脂影響的分子機制，我們計畫作兩年的研究，從腸道生理的差異及肝臟糖新生作用的差異來切入，期待釐清高、低分子量幾丁聚醣對血脂、血糖影響不同之機制。(1) 第一年: 透過腸道生理的變化來比較高、低分子量幾丁聚醣對脂質的影響機制之探討。(2) 第二年: 透過肝臟榶新生作用的不同來比較不同分子量幾丁聚醣對攝食高果糖動物榶代謝的影響機制之探討。" "Recently, we focused on the investigation the mechanism of reducing plasma glucose and lipids by chitosan. We found that chitosan decreases plasma lipids through increasing bile acid excretion, fecal lipids and intestinal short chain fatty acids production. Lower plasma glucose may be due to the reduced hepatic gluconeogensis and intestinal disaccharidase activities after chitosan treatment. However, a comparative effect of high molecular weight and low molecular weight chitosan on plasma lipids and glucose is controversy. It is worth to note that high molecular weight chitosan has better ability of decreasing plasma lipids and glucose than low molecular weight chitosan. The mechanism is still unknown. It is possible that the intestinal MTTP (Microsomal triglyceride transfer protein), Angptl 4(Angiopoietin-like proteins 4) and the fatty acid transporter (FATP1 and FABP4) may play important role in regulation of lipid absorption in animal fed high or low molecular weight chitosan diet. On the other hand, the liver gluconeogensis may be different after different molecular weight chitosan treatment. In order to investigate the mechanism of ameliorating plasma lipids and glucose by different molecular weight chitosan, this project including 2-years plan will be studied. 1st year: A comparative effect of high molecular weight and low molecular weight chitosan on plasma lipids in hamsters with high fat diet-induced hyperlipidemia. 2nd year: A comparative effect of high molecular weight and low molecular weight chitosan on plasma glucose in high-fructose-diet-impaired glucose-tolerance rat model."

DSpace CRIS

Molecular Mechanism on Comparative Effect of High and Low Molecular Weight Chitosan on Reducing Plasma Lipids and Glucose

基本資料

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