The Occurrence of PPCPs in the Northern and Central Coastal Water of Taiwan

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Project title

Code/計畫編號

MOST104-2611-M019-017

Translated Name/計畫中文名

台灣北部至中部海域海水中抗生素藥殘留分佈研究

Project Coordinator/計畫主持人

Tien-Hsi Fang

Funding Organization/主管機關

National Science and Technology Council

Department/Unit

Department of Marine Environmental Informatics

Website

https://www.grb.gov.tw/search/planDetail?id=11585031

Year

2015

Start date/計畫起

01-08-2015

Expected Completion/計畫迄

31-07-2016

Bugetid/研究經費

1282千元

ResearchField/研究領域

海洋科學

"現在研究醫療藥物在海洋環境之殘留分佈與宿命，幾乎是海洋污染研究之顯學，最近研究也顯示台灣西南沿海海域已遭受到醫療藥物殘留污染(Jiang et al., 2014)，但對於台灣北部至中部沿海海域之醫療藥物殘留分佈之瞭解仍不多，有鑑於此，此申請計畫乃研究台灣北部至中部沿海海域之醫療藥物殘留分佈與其宿命研究，預研究分析之殘留藥物計有磺胺類抗生素(如Sulfadiazine、 Sulfamethoxazole、Sulfathiazole、Sulfamethazine、Sulfamonomethoxine、 Sulfadimethoxine)、巨環素類抗生素(Erythromycin-H2O、Clarithromycin、Roxithromycin、 Tylosin)、非類固醇消炎止痛藥(acetaminophen、ibuprofen、與ketoprofen)與降血脂及降膽固醇用藥(Clofibic acid、Gemfibrozil、Bezafibrate)，本計畫擬使用HLB 固相管柱濃縮萃取樣水中之待測殘留醫療藥物，之後以析液相層析質譜儀 (LC/MS-MS): Agilent 1100 型液相層析儀/ ABI API 4000Q 型四極桿串聯式質譜儀分析殘留醫療藥物濃度。""The concern of pharmaceutical personal chemical compounds (PPCPs) in the marine environment is gradually being increasing in the recent study. It has been shown that the south western coastal seawater of Taiwan was contaminated by the PPCPs (Jiang et al., 2014). However, the known of the occurrence of PPCPs in the north to central coastal seawater of Taiwan is very limit. The purposes of this project are to study the spatial and temporal distribution and fate of PPCPs, such as the sulfonamide antibiotics (sulfadiazine, sulfamethoxazole, sulfathiazole, sulfamethazine, sulfamonomethoxine, sulfadimethoxine), the macrolide antibiotics (erythromycin-H2O, clarithromycin, roxithromycin, tylosin), the NSAIDS (acetaminophen, ibuprofen, ketoprofen), the lipid regulator and cholesterol lowering drug (clofibic acid, gemfibrozil, Bezafibrate) in the north to central coastal seawater of Taiwan. The PPCPs dissolved concentrations in seawater samples will be determined by means of the solid-phase extraction method combined with LC/MS/MS. The result of the present study can be an indicator of the PPCPs pollution status in north to central coastal seawater of Taiwan and the data can be used when assessing the marine ecological system."

Keyword(s)

台灣海域
磺胺類抗生素
巨環素類抗生素
降膽固醇藥
液相層析串聯式質譜儀
sulfonamide antibiotics
macrolide antibiotics
NSAIDS
lipid regulator and cholesterol lowering drug
Taiwan coastal seawater of Taiwan
LC/MS/MS

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The Occurrence of PPCPs in the Northern and Central Coastal Water of Taiwan

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