Multifunctional Silica Nanoparticle Drug Delivery System with Materials of Marine Origin

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Project title

Code/計畫編號

MOST106-2113-M019-003

Translated Name/計畫中文名

具有海洋特色的多功能二氧化矽奈米粒子的藥物系統

Project Coordinator/計畫主持人

Hsiu-Mei Lin

Funding Organization/主管機關

National Science and Technology Council

Department/Unit

Department of Bioscience and Biotechnology

Website

https://www.grb.gov.tw/search/planDetail?id=12234385

Year

2017

Start date/計畫起

01-08-2017

Expected Completion/計畫迄

01-07-2018

Bugetid/研究經費

1000千元

ResearchField/研究領域

化學

癌症的死亡率在所有人類的疾病中一直是偏高的，然而常見的抗癌藥物在使用後都有很高的副作用，因此研究具有能降低使用藥量以及達到特定部位標靶的奈米藥物載體，成為治療癌症的新方向。海洋的資源轉化再利用是現今相當熱門的研究方向。本研究將矽藻土做為兩種研究方向，分別是研磨跟酸處理，將矽藻土研磨所得奈米粒子作為一種天然的藥物載體(DSN)，以及使用價值較低的矽藻土提取其生物矽當作矽來源，來製備具有較高價值的中孔洞二氧化矽奈米粒子(dMSN)，作為藥物傳遞系統。並對於藥物釋放的性能進行探討。首先在多功能中孔洞二氧化矽奈米粒子(dMSN)及矽藻土奈米粒子(DSN)中摻雜分別具有螢光顯影功能的鑭系金屬，使材料具有雙重顯影與追蹤的功能。本研究的藥物控制釋放是使用雙硫鍵(S-S)官能化dMSN 和DSN，接著在材料的孔洞中載入褐藻醣膠(fucoidan)並在孔壁上修飾上雙硫鍵當守門員以保護藥物不會過早釋放。最後在修飾上標靶性的分子葉酸(Folic acid)，及胜肽(TAT peptide)，讓材料成為一個具有雙重靶向及顯影追蹤的新穎智慧型藥物載體。本研究的大綱主要分為四個部分: (i)製備具有磁共振顯影及光學顯影特性之dMSN 和DSN (ii)雙硫鍵控制釋放系統，(iii)載入褐藻糖膠，(iv)最後嫁接上標靶，最後比較這兩種多功能奈米粒子藥物傳送系統之間的差異。 Mortality rate of cancer has always been high among all human diseases, however taking commonly used anti-cancer drugs can cause high side effects. Therefore, research of nano drugs carrier for reducing dosage and reaching specific place through targets has become a new direction for the treatment of cancer. Ocean resources conversion and reuse is now a very popular research direction. This research divided into two program, respectively grinding and acid treatment, we crushed diatomite into nanoparticles as a natural drug carrier (DSN), another is preparation high economic value of mesoporous silica nanoparticles (dMSN) by using low economic value diatomite’s sodium silicate as a drug delivery system, then we discuss the properties of drug release. Fluorescent and magnetic properties of the lanthanide metals doped with dMSN and DSN, make the nanocarrier have magnetic resonance and fluorescent imaging property. Drug release switch mechanism was use disulfide bonds (S-S) functionalized modification dMSN and DSN, Then the addition of a ‘gatekeeper’ on the loaded-fucoidan-dMSN and DSN pore. acting as a controlled release system upon cell entry, protection of the drug will not be released early. Finally, the folic acids and TAT peptides are grafting in dMSN surface as targeting ligands, making our materials as a smart dual-targeting and image-tracking novel nanocarrier. This study is mainly divided into four parts: (i) preparation of DSN and dMSN that have magnetic resonance and fluorescent imaging property, (ii) the addition of the drug control release system, (iii) loading fucoidan, and finally, (iv) grafting target ligand on to cell surface of dMSN and DSN. Finally, the difference between these two multifunctional nanoparticles drug delivery system were compared.

Keyword(s)

矽藻
多功能奈米粒子
藥物輸送
標靶
控制釋放
雙重影像
diatom
multifunctional nanoparticles
drug delivery
target
controlled release
dual image

DSpace CRIS

Multifunctional Silica Nanoparticle Drug Delivery System with Materials of Marine Origin

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