Multifunctional Silica Nanoparticle Drug Delivery System with Materials of Marine Origin(II)

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Project title

Code/計畫編號

MOST107-2113-M019-001

Translated Name/計畫中文名

具有海洋特色的多功能二氧化矽奈米粒子的藥物系統(II)

Project Coordinator/計畫主持人

Hsiu-Mei Lin

Funding Organization/主管機關

National Science and Technology Council

Department/Unit

Department of Bioscience and Biotechnology

Website

https://www.grb.gov.tw/search/planDetail?id=12675276

Year

2018

Start date/計畫起

01-08-2018

Expected Completion/計畫迄

01-07-2019

Bugetid/研究經費

1000千元

ResearchField/研究領域

化學

本研究將承襲先前將矽藻土研磨及酸處理的研究成果，將矽藻土研磨後得奈米粒子作為天然的藥物載體(DSN)，以及使用經濟價值較低的矽藻土並提取其生物矽當作矽來源，來製備具有較高價值的中孔洞二氧化矽奈米粒子(dMSN)，並摻雜分別具有螢光顯影及磁共振顯影功能的鑭系金屬，使材料具有雙重顯影與追蹤的功能。現今常見的抗癌藥物對於癌細胞沒有選擇性，造成患者使用後會有嚴重的副作用，因此研究具有靶向性且能夠降低使用藥量的奈米載體，是治療癌症的新熱門趨勢。接下來本研究將著重在藥物控制釋放系統，先將dMSN和DSN修飾上胜肽(TAT peptide)，在材料的孔洞中載入褐藻醣膠後，利用對pH值敏感的分子將dMSN和DSN官能化，使該分子在孔壁上當守門員以保護藥物不會過早釋放，最後再修飾上標靶性的分子葉酸(Folic acid)，讓材料成為一個具有雙重靶向及顯影追蹤且能控制釋放藥物的新穎智慧型藥物載體。本研究的大綱主要分為四個部分，將具有磁共振顯影及光學顯影特性之dMSN和DSN：(i) 接上細胞核標靶TAT peptide、(ii) 載入褐藻醣膠、(iii) 加上pH值控制釋放系統、(iv) 嫁接上細胞膜標靶Folic acid，最後比較這兩種多功能奈米粒子藥物傳送系統之間的差異。 According to our early research of diatomite grinding and acid treatment, we crushed diatomite into nanoparticles as a natural drug carrier (DSN). We use diatomite’s sodium silicate, which have low economic value to prepare mesoporous silica nanoparticles (dMSN), which have high value. Then we use the fluorescent and magnetic properties of the lanthanide metals doped with dMSN and DSN to modify the nanocarrier with magnetic resonance and fluorescent imaging property. Recently, anti-cancer drugs do not have selectivity on cancer cell and cause serious side effects . Therefore, research on nano drug carriers of targeting and reducing dosage has become a new trend in the treatment of cancer. This research will focus on drug release control system. First, use TAT peptide grafting on dMSN and DSN surface as nuclear membrane targeting ligands. After loading fucoidan, the addition of molecular which is sensitive to pH act as a ‘gatekeeper’ in front of the loaded-fucoidan-dMSN and DSN pore, and also act as a drug release control system before it enter the cell, it protect the drug from release to early. Finally, folic acids had been grafted on dMSN and DSN surface as cell membrane targeting ligands, our material then become a smart dual-targeting and image-tracking novel nanocarrier. This study can be mainly divided into four parts: (i) Grafting target ligand (TAT peptide) on the material for targeting the nuclear membrane. (ii) Load fucoidan into the material. (iii) The addition of the pH dependent drug release control system. (iv) Graft target ligand (Folic acid) on cell membrane surface with dMSN and DSN. Finally, compare the differences between these two multifunctional nanoparticles drug delivery system.

Keyword(s)

矽藻
多功能奈米粒子
藥物輸送
標靶
控制釋放
雙重影像
diatom
multifunctional nanoparticles
target
controlled release
dual image
drug delivery

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Multifunctional Silica Nanoparticle Drug Delivery System with Materials of Marine Origin(II)

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