Marine Featured Drug Delivery System Combined Photothermal and Magnetic Hyperthermia Therapy with Thermal Release Control

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Project title

Code/計畫編號

MOST109-2113-M019-002

Translated Name/計畫中文名

具有海洋特色的光熱與磁熱治療並具備熱控制釋放之藥物遞送系統

Project Coordinator/計畫主持人

Hsiu-Mei Lin

Funding Organization/主管機關

National Science and Technology Council

Department/Unit

Department of Bioscience and Biotechnology

Website

https://www.grb.gov.tw/search/planDetail?id=13542046

Year

2020

Start date/計畫起

01-08-2020

Expected Completion/計畫迄

31-07-2021

Bugetid/研究經費

950千元

ResearchField/研究領域

化學

接有標靶的藥物傳遞系統結合二種以上治療方式已被證實具有更好的治療效果，例如將化療協同光熱或是磁熱療法後能夠更快速殺死目標癌症組織；本研究將結合三種治療方式，打算將標靶奈米粒子攜帶化療藥物並結合光熱與磁熱療法，且利用材料光照/磁場誘發發熱的特性來控制藥物釋放。首先在合成時使用矽藻土(Diatom) 作為生物矽來源並摻雜磁熱療金屬釓 (Gd) ，再載入光熱療用金屬鉍 (Bi) 以及有海洋特色的化療藥物褐藻糖膠 (Fucoidan)，最後在奈米粒子的表面修飾上溫控高分子 PEGMA 作為藥物熱控制釋放守門人，接著接上標靶透明質酸 (Hyaluronic Acid, HA) 後合成出光熱治療暨磁熱治療結合熱控制釋放之海洋特色的智慧型奈米藥物傳遞系統。光熱治療因為光照深度有限又因為組織會吸收光能，所以只能被用於淺層皮膚腫瘤治療，而磁熱治療則是可以克服這項缺點；因此本計畫預期開發一種多功能的奈米粒子，將藥物傳遞系統結合光熱與磁熱治療，並將材料放出的熱作為藥物的溫控釋放開關，希望將來在臨床治療上可以針對腫瘤種類與位置選擇相對應的最佳治療方式。 Cancer therapies that combine more than two treatments have been proven to have better efficiency. For example, synergistic therapy that combines chemotherapy with photothermal or magnetic-thermal treatments exhibit rapid extinction of cancer cells. This project combines three therapies: including targeting nanoparticle that loaded chemotherapy drugs with photothermal and magnetic hyperthermia treatments. While making the best use of the thermal characteristic from itself, we use a temperature sensitive polymer: PEGMA act as temperature controlled drug release gate keeper. In practical, we first synthesis mesoporous silica nanoparticles (MSNs) while using biological silica source from diatom, and also dope in magnetic hyperthermia metal gadolinium (Gd) at the same process. Then load in bismuth (Bi) for phototrermal treatment and fucodian as marine feature chemotherapy drug. At last, we modify PEGMA as control release gate keeper and the cell membrane target ligand hyaluronic acid (HA) on the surface of MSNs. Finally, this marine featured intelligence nano drug delivery system combined photothermal and magnetic hyperthermia therapy is well prepared. Due to the tissue absorption of NIR, photothermal therapy is limited by the depth, while magnetic hyperthermia can overcome this disadvantage. This project designs a novel nanoparticle that combines the advantages of those two hyperthermia treatment and using their heat for drug release control. We expect this multifunction nanoparticle can improve the efficiency of nowadays cancer treatments by being useful in any location of organism while clinical situation.

Keyword(s)

矽藻
多功能奈米粒子
藥物輸送
雙重影像
標靶
結合治療
光熱治療
磁熱治療
熱控制釋放
diatom
multifunctional nanoparticles
drug delivery
dual imaging
target
synergistic therapy
photothermal therapy
magnetic hyperthermia therapy
thermal controlled release

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Marine Featured Drug Delivery System Combined Photothermal and Magnetic Hyperthermia Therapy with Thermal Release Control

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