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  1. National Taiwan Ocean University Research Hub

Conditions of Fermenting Sorghum Distillery Residues by Lactic Acid Bacteria and Evaluation of the Neuroprotective Effect of the Fermented Product Using a Cell Model

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Project title
Conditions of Fermenting Sorghum Distillery Residues by Lactic Acid Bacteria and Evaluation of the Neuroprotective Effect of the Fermented Product Using a Cell Model
Code/計畫編號
NSTC112-2221-E019-004
Translated Name/計畫中文名
乳酸菌發酵高粱酒粕之條件及以細胞膜式探討發酵產物對腦神經細胞保護活性
 
Project Coordinator/計畫主持人
Guo-Jane Tsai
Funding Organization/主管機關
National Science and Technology Council
 
Department/Unit
Department of Food Science
Website
https://www.grb.gov.tw/search/planDetail?id=15422433
Year
2023
 
Start date/計畫起
01-08-2023
Expected Completion/計畫迄
31-07-2024
 
Bugetid/研究經費
1410千元
 
ResearchField/研究領域
食品科技(工)
 

Description

Abstract
巴金森氏症(PD)是最常見之神經退化性運動失調疾病,台灣罹患 PD 人口每年大約以 8% 的速度增加。目前高梁酒粕或其他酒粕之應用研究主要在動物飼料添加劑、生質能源、活性碳及皮膚保健等領域,甚少研究進行酒粕發酵及應用於對腦神經細胞的保護的領域。本研究以乳酸菌進行高梁酒粕發酵,建立發酵條件、分析多酚與類黃酮化合物及活性物質萃取方法,並以PD細胞膜式初步確認發酵產物對抗PD誘導劑,保護腦神經細胞的功效及作用機轉。除了可開發功能性益生菌發酵產品,有效加值酒廠酒粕,創造循環經濟,因而具產業應用性外,也具學術價值。
 
Keyword(s)
巴金森氏症
神經母細胞瘤細胞
6-羥基多巴胺
高梁酒粕
乳酸菌發酵
多酚/類黃酮
神經細胞保護功效
Parkinson's disease
Neuroblastoma cells
6-hydroxydopamine
Sorghum distillery residue
Lactic acid bacteria fermentation
Polyphenols/flavonoids
Neuroprotective effect
 
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